Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1052 clinical trials
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Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular …

cancer diagnosis
clinical decision-making
precision medicine
residual disease
solid tumour
  • 0 views
  • 11 Apr, 2021
  • 1 location
None
A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer

This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are. A side effect is anything the drug does besides treating cancer. …

cyclophosphamide
t-cell lymphoma
erbb2
vincristine
stem cell transplantation
  • 2 views
  • 29 Nov, 2021
  • 24 locations
None
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)

This is a randomized open-label multicentre Phase III superiority study of the effect of adding SBRT to the standard of care treatment on overall survival in patients with rare oligometastatic cancers. Patients will be randomized in a 1:1 ratio between current standard of care treatment vs. standard of care treatment …

systemic therapy
metastasis
brain metastases
  • 0 views
  • 09 Jul, 2021
  • 3 locations
None
Efficacy of Spartalizumab Across Multiple Cancer-types in Patients With PD1-high mRNA Expressing Tumors

This is an open-label, single arm, non-randomized, multicenter phase II study to evaluate the efficacy of spartalizumab in monotherapy in metastatic patients with Programmed Death-1 (PD1)-high-expressing tumors.

measurable disease
alopecia
cancer
  • 0 views
  • 22 Aug, 2021
  • 10 locations
None
MRx0518 in Patients With Solid Tumours Waiting Surgical Removal of the Tumour

The primary objective is to determine the safety and tolerability of the novel compound, MRx0518 in patients with solid tumours at 30 days post-surgery. 20 participants will receive open label MRx0518 in a preliminary safety phase. After successful evaluation by the Independent Safety Monitoring Committee (IDMC), a further 100 participants …

cancer chemotherapy
cancer
  • 13 views
  • 23 Jan, 2021
  • 1 location
None
Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer.

pancreatic adenocarcinoma
bladder cancer
esophagus cancer
immunostimulants
gastric cancer
  • 139 views
  • 31 May, 2021
  • 23 locations
None
A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies

This is a Phase 1/1b, multicenter, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of AB308 in combination with zimberelimab (AB122) in participants with advanced malignancies.

  • 0 views
  • 13 Oct, 2021
  • 20 locations
None
Trans-Artery/Intra-Tumor Infusion of Checkpoint Inhibitors for Immunotherapy of Advanced Solid Tumors

This trial was designed to investigate the safety, response rates and survival outcomes of patients with advanced solid tumors by trans-artery/intra-tumor infusion of PD1/PDL1 antibody and/or CTLA4 antibody ipilimumab and to compare their differences.

solid tumors
ipilimumab
total bilirubin
measurable disease
solid tumour
  • 25 views
  • 23 Jan, 2021
  • 1 location
None
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or Pembrolizumab), and Imiquimod Cream, Bevacizumab, Gemcitabine / Carboplatin / Bevacizumab, Topotecan, and Pegylated liposomal doxorubicin (PLD) …

bladder cancer
cancer treatment
paclitaxel
cancer of the ovary
ovarian cancer
  • 20 views
  • 14 Nov, 2021
  • 8 locations
None
Dose Escalation of DF6002 in Patients With Advanced Solid Tumors and Expansion in Selected Indications

This study is a Phase 1/2, open-label, dose-escalation study with a consecutive parallel-group efficacy expansion study, designed to determine the safety, tolerability, PK, pharmacodynamics, and preliminary anti-tumor activity of DF6002 as monotherapy and in combination with nivolumab.

cancer treatment
major surgery
EGFR
progesterone receptor
hepatitis
  • 12 views
  • 02 Dec, 2021
  • 14 locations