Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1030 clinical trials
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Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Patients with histologically or cytologically confirmed advanced melanoma, renal cell carcinoma, NSCLC, HCC (Child Pugh Class A only), MSI-High solid tumors, Urothelial Cancer, GE junction/Gastric Adenocarcinoma, or HNSCC for which current standard of care treatment for their stage of disease would be with Pembrolizumab or Nivolumab monotherapy, who meet eligibility …

progressive disease
solid tumor
cancer
monoclonal antibodies
nivolumab
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Risk Factors of Immune-ChEckpoint Inhibitors MEdiated Liver Gastrointestinal Endocrine and Skin Toxicity

This is a prospective cohort study aiming to establish clinical and biological risk factors of immune-checkpoint inhibitors (ICIs) mediated toxicity. ICIs have recently revolutionized cancer treatment and already considered as a new standard of care for lung cancer, renal carcinoma, melanoma and hepatocellular carcinoma. However, the variability in response rates …

  • 0 views
  • 06 May, 2021
  • 2 locations
None
TiTAN-1: Safety Proliferation and Persistence of GEN-011 Autologous Cell Therapy

TiTAN-1 is a first-in-human study of GEN-011, an experimental treatment being evaluated in adult patients with advanced cancer. GEN-011 is a T cell therapy made specific to each patient, using the patient's own circulating immune cells. First, Genocea confirms which cancer proteins are recognized already by each patient's T cells …

cancer
urothelial carcinoma
measurable disease
lung cancer
cyclophosphamide
  • 0 views
  • 25 Jul, 2021
  • 5 locations
None
GI-101 as a Single Agent or in Combination With Pembrolizumab Lenvatinib or Local Radiotherapy in Advanced Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-101 as a single agent or in combination with pembrolizumab, lenvatinib or local radiotherapy (RT) over a range of advanced and/or metastatic solid tumors.

pembrolizumab
lenvatinib
cancer
measurable disease
HIV Infection
  • 0 views
  • 14 Aug, 2021
  • 2 locations
None
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and …

erbb2
cancer
pancreatic adenocarcinoma
gastric adenocarcinoma
lung carcinoma
  • 0 views
  • 04 Oct, 2021
  • 1 location
None
Family History App in Personalized Medicine

A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment. In practice, complete FH is rarely collected or entered into the electronic medical record (EMR). The Family History Screening Questionnaire is a survey patients complete …

Accepts healthy volunteers
cancer
heart disease
precision medicine
  • 0 views
  • 10 Oct, 2021
  • 1 location
None
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery

This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope …

probe
cancer
sentinel lymph node biopsy
indocyanine green
mammogram
  • 29 views
  • 03 Feb, 2021
  • 2 locations
None
Autologous and Allogeneic Whole Cell Cancer Vaccine for Metastatic Tumors

This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with melanoma and colorectal, gastric, ovarian, breast, lung …

cancer vaccine
metastasis
tumor cells
neutrophil count
cancer
  • 40 views
  • 23 Jan, 2021
  • 1 location
None
Oral STAT3 Inhibitor TTI-101 in Patients With Advanced Cancers

Many patients have cancers that have increased activity of a protein called STAT3 that contributes critically to the development and growth of their cancer. Despite our knowledge of STAT3's importance to cancer, scientists and doctors have not developed a drug that targets it and that patients can take to treat …

kidney function tests
solid neoplasm
renal function
cancer
measurable disease
  • 167 views
  • 08 Oct, 2021
  • 1 location
None
Familial Investigations of Childhood Cancer Predisposition

NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic …

childhood cancer
cancer
familial cancer
genetic testing
biological factors
  • 213 views
  • 21 May, 2021
  • 1 location