Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 133 clinical trials
Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children

This pilot will study the feasibility and exploratory efficacy of using Cabozantinib for recurrent or refractory central nervous system tumors for which there are no curative options. Patients will also be followed for safety, time to progression, event free survival and overall survival

blood transfusion
cytotoxic chemotherapy
epilepsy
astrocytoma, anaplastic
renal function test
  • 32 views
  • 02 Sep, 2021
  • 1 location
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers

Background People cope with cancer in different ways. Mindfulness means focusing on the present moment with an open mind. Researchers want to see if this can help children and young adults with a high-grade high-risk cancer with poor prognosis. Objective To learn if mindfulness is feasible and acceptable for children …

cancer
KIT
myeloid leukemia
brain tumor
lymphoid leukemia
  • 14 views
  • 12 Sep, 2021
  • 1 location
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

In this research study the investigators want to learn more about the safety of the study drug, PTC596 has when taken during radiation. The investigators also want to learn about the effects, if any, these drugs have on children and young adults with brain tumors. The investigators are asking people …

blood transfusion
diffuse intrinsic pontine glioma
total resection
epilepsy
brainstem tumor
  • 1 views
  • 05 Sep, 2021
  • 10 locations
H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

This is 3-arm, multicenter study that will be conducted through the Pacific Pediatric Neuro-oncology Consortium (PNOC). This study will assess the safety and immune activity of a synthetic peptide vaccine specific for the H3.3.K27M epitope given in combination with poly-ICLC and the H3.3.K27M epitope given in combination with poly-ICLC and …

neutrophil count
blood transfusion
diffuse intrinsic pontine glioma
epilepsy
lipase
  • 93 views
  • 03 Sep, 2021
  • 16 locations
Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

Background People with von Hippel-Lindau (VHL) can have problems with a variety of organs, such as the pancreas. The disease can cause tumors of the pancreas. This can result in life-threatening complications. Researchers want to learn more about these pancreatic tumors and how to better detect them. This may help …

pet/ct scan
cyst
dotatate
ct scan
genetic testing
  • 0 views
  • 12 Sep, 2021
  • 1 location
Pembrolizumab With Liver-Directed or Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors and Liver Metastases

This pilot phase II trial studies how effective pembrolizumab and liver-directed therapy or peptide receptor radionuclide therapy are at treating patients with well-differentiated neuroendocrine tumors and symptomatic and/or progressive tumors that have spread to the liver (liver metastases). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …

international normalized ratio
neutrophil count
metastasis
pembrolizumab
monoclonal antibodies
  • 15 views
  • 03 Sep, 2021
  • 1 location
Evaluating Therapeutic Response to Novo-TTF

This study is to assess the utility of high resolution 3D echo planar magnetic resonance spectroscopy (3D EPSI) in monitoring Novo-TTF response in glioblastoma multiforme (GBM) patients.

karnofsky performance status
gliadel wafer
tumor treating fields therapy
MRI
gliadel
  • 23 views
  • 15 Sep, 2021
  • 1 location
ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

The primary objective of this phase II trial is to determine the efficacy and safety of ONC201, an oral small molecule imipridone DRD2 antagonist, in adult subjects with recurrent high-grade glioma. This study will test the research hypothesis that histone H3 K27M mutation sensitizes to oral administration of ONC201 in …

neutrophil count
recurrent malignant glioma
bilateral tubal ligation
bevacizumab
dna sequencing
  • 24 views
  • 15 Sep, 2021
  • 9 locations
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

Background Glioma is a type of brain cancer. Some of these tumors have gene mutations. These mutations can cause a substance called 2-HG to build up in the brain. This makes the tumors more aggressive. Researchers want to better understand 2-HG buildup in the brain. They hope this can help …

dna sequencing
brain tumor
MRI
cancer
measurable disease
  • 0 views
  • 12 Sep, 2021
  • 1 location
Bortezomib and Temozolomide in Recurrent Glioblastoma With Unmethylated MGMT Promoter (BORTEM-17)

This phase IB/II trial is designed to investigate the safety and survival benefits for patients with recurrent glioblastoma with unmethylated MGMT promoter treated with Bortezomib and Temozolomide in a specific schedule.

blood transfusion
karnofsky performance status
recurrent glioblastoma
platelet count
recurrent tumor
  • 48 views
  • 04 Sep, 2021
  • 2 locations