Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 130 clinical trials
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

Background Gliomas are the most common malignant brain tumors. Some have certain changes (mutations) in the genes IDH1 or IDH2. If there are a high number of mutations in a tumor, it is called hypermutator phenotype (HMP). The drug nivolumab helps the immune system fight cancer. Researchers think it can …

MRI
nivolumab
somatic mutations
cancer
brain mri
  • 38 views
  • 12 Sep, 2021
  • 1 location
Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

This randomized phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that have spread to other places in the body (advanced). Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine …

everolimus
history of allergic reaction
somatostatin
cancer
international normalized ratio
  • 190 views
  • 22 Sep, 2021
  • 290 locations
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

This is a surgical biospecimen collection study. The purpose of this study is to understand how much of two drugs (dabrafenib and trametinib) are able to penetrate brain tumors and turn off the RAF signaling pathway. This is important because these drugs are currently FDA approved for other tumors and …

dabrafenib
ganglioglioma
primary brain tumors
anaplastic astrocytoma
astrocytoma, anaplastic
  • 28 views
  • 16 Sep, 2021
  • 6 locations
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

This phase 3 trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type …

MRI
metastatic disease
initial diagnosis
seizure
carboplatin
  • 14 views
  • 22 Sep, 2021
  • 53 locations
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

This phase II/III trial compares the usual treatment with radiation therapy and temozolomide to radiation therapy in combination with immunotherapy with ipilimumab and nivolumab in treating patients with newly diagnosed MGMT unmethylated glioblastoma. Radiation therapy uses high energy photons to kill tumor and shrink tumors. Chemotherapy drugs, such as temozolomide, …

MRI
nivolumab
glioblastoma multiforme
tumor resection
cancer
  • 1 views
  • 23 Sep, 2021
  • 150 locations
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers

Background People cope with cancer in different ways. Mindfulness means focusing on the present moment with an open mind. Researchers want to see if this can help children and young adults with a high-grade high-risk cancer with poor prognosis. Objective To learn if mindfulness is feasible and acceptable for children …

lymphoid leukemia
myeloid leukemia
KIT
brain tumor
cancer
  • 14 views
  • 12 Sep, 2021
  • 1 location
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in combination with adoptive cell therapy (Total tumor mRNA-pulsed autologous Dendritic Cells (DCs) (TTRNA-DCs), Tumor-specific ex vivo expanded autologous lymphocyte …

granulocyte colony stimulating factor
depo-provera
neutrophil count
colony stimulating factor
bone marrow procedure
  • 0 views
  • 22 Sep, 2021
  • 2 locations
Neoadjuvant Lenvatinib Plus Pembrolizumab in Merkel Cell Carcinoma

This is a single arm trial of participants with Merkel cell carcinoma receiving a combination of lenvatinib plus pembrolizumab.

  • 0 views
  • 22 Sep, 2021
  • 1 location
Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

Background People with von Hippel-Lindau (VHL) can have problems with a variety of organs, such as the pancreas. The disease can cause tumors of the pancreas. This can result in life-threatening complications. Researchers want to learn more about these pancreatic tumors and how to better detect them. This may help …

pet/ct scan
ct scan
neuroendocrine tumor
genetic testing
cyst
  • 0 views
  • 12 Sep, 2021
  • 1 location
MR-guided LITT Therapy in Patients With Primary Irresectable Glioblastoma

Objective: In preparation of a randomized controlled trial, the investigators aim to assess pilot data on technical feasibility and safety of laser interstitial thermal therapy (LITT) at Radboud University Medical centre and to assess practical feasibility of a randomized study in patients with primary irresectable glioblastoma, as compared with standard …

MRI
karnofsky performance status
  • 0 views
  • 19 Sep, 2021
  • 1 location