Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 126 clinical trials
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Background A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy. When the tumor grows back, surgery or chemotherapy may not be possible or may no longer work. Repeat radiation therapy or re-irradiation, is …

MRI
combined modality therapy
cytotoxic chemotherapy
temozolomide
gliosarcoma
  • 41 views
  • 25 Sep, 2021
  • 1 location
Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

This phase I trial studies the side effects and best dose of MDM2 inhibitor KRT-232 in treating patients with glioblastoma (brain cancer) that is newly diagnosed or has come back (recurrent). MDM2 inhibitor KRT-232 may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

serum pregnancy test
karnofsky performance status
cytotoxic chemotherapy
thromboplastin
interferon
  • 127 views
  • 16 Sep, 2021
  • 3 locations
Protein Phosphatase 2A Inhibitor in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

gliosarcoma
renal function test
platelet count
oligodendroglioma
recurrent disease
  • 22 views
  • 12 Sep, 2021
  • 1 location
Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Background Glioblastoma is a type of brain cancer. Treatments include radiation, chemotherapy, and surgery. But survival rates are poor. Researchers think that the drug selinexor, when combined with chemotherapy and radiation, might help. Objective To learn the highest dose of selinexor that people with brain cancer can tolerate when given …

ct scan
MRI
platelet count
therapeutic agent
temozolomide
  • 43 views
  • 12 Sep, 2021
  • 1 location
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

Background More than 130 primary tumors of the central nervous system (CNS) have been identified. Most affect less than 1,000 people in the United States each year. Because these tumors are so rare, there are few proven therapies. This study will test whether the immunotherapy drug nivolumab is an effective …

gilbert's disease
absolute neutrophil count
carcinoma
nivolumab
pineoblastoma
  • 120 views
  • 12 Sep, 2021
  • 10 locations
INCMGA00012 and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas

In this study, the investigators propose to combine INCMGA00012 with radiation therapy (RT) and bevacizumab with or without epacadostat in the treatment of recurrent glioblastoma (GBM). The investigators hypothesize that this combination provides a powerful synergy between RT and immune modulators to produce more robust anti-tumor immune response, induce tumor …

aptt
blood transfusion
neutrophil count
measurable disease
immunotherapeutic agent
  • 0 views
  • 22 Sep, 2021
  • 4 locations
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

This phase II/III trial compares the usual treatment with radiation therapy and temozolomide to radiation therapy in combination with immunotherapy with ipilimumab and nivolumab in treating patients with newly diagnosed MGMT unmethylated glioblastoma. Radiation therapy uses high energy photons to kill tumor and shrink tumors. Chemotherapy drugs, such as temozolomide, …

tumor resection
MRI
blood transfusion
brain mri
temozolomide
  • 1 views
  • 23 Sep, 2021
  • 150 locations
Immunotherapy (Nivolumab and Ipilimumab) Before and After Surgery for the Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

This phase I trial studies the side effects of nivolumab and ipilimumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help …

gilbert's syndrome
cytotoxic chemotherapy
interferon
interleukins
nivolumab
  • 0 views
  • 12 Sep, 2021
  • 12 locations
177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma

Children and adolescents diagnosed with medullablastoma and with recurrent or refractory to frontline therapy will be treated with 177Lu-DTPA-omburtamab, which is a radioactive labelling of a murine monoclonal antibody targeting B7-H3.

  • 0 views
  • 10 Sep, 2021
  • 10 locations
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

Background Gliomas are the most common malignant brain tumors. Some have certain changes (mutations) in the genes IDH1 or IDH2. If there are a high number of mutations in a tumor, it is called hypermutator phenotype (HMP). The drug nivolumab helps the immune system fight cancer. Researchers think it can …

IDH2
MRI
platelet count
brain mri
blood urea nitrogen
  • 38 views
  • 12 Sep, 2021
  • 1 location