Urothelial Tract Cancer Clinical Trials

A listing of Urothelial Tract Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 54 clinical trials
Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)

The purpose of this research study is to determine the safety and efficacy of CPI-613 (devimistat) in the treatment of advanced biliary tract cancer when used in combination with standard of care chemotherapy (gemcitabine plus cisplatin) compared to gemcitabine plus cisplatin alone. This research study has two parts: In the …

biliary tract cancer
gemcitabine
carcinoma
measurable disease
cisplatin/gemcitabine
  • 9 views
  • 04 Jun, 2022
  • 9 locations
Neoadjuvant Chemotherapy With Gemcitabine Plus Cisplatin Followed by Radical Liver Resection Versus Immediate Radical Liver Resection Alone With or Without Adjuvant Chemotherapy in Incidentally Detected Gallbladder Carcinoma After Simple Cholecystectomy or in Front of Radical Resection of BTC (GAIN)

Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC)

gemcitabine
cholangiocarcinoma
carcinoma
international normalized ratio
aptt
  • 4 views
  • 18 Feb, 2022
  • 1 location
Adjuvant Capecitabine vs Gemcitabine Plus Cisplatin in Resected Extrahepatic Cholangiocarcinoma

There is no proven adjuvant treatment after curative surgical resection in patients with cholangiocarcinoma, although previous meta-analysis suggested potential survival benefit of adjuvant chemotherapy or radiotherapy in patients with lymph node-positive resected cholangiocarcinoma. Despite of lack of level 1 evidence and no data which regimen is optimal, adjuvant chemotherapy is …

absolute neutrophil count
gemcitabine
cholangiocarcinoma
carcinoma
cancer
  • 15 views
  • 24 Feb, 2022
  • 1 location
Apatinib for Advanced Biliary Carcinoma

This is a phase II open-label, one-arm, single-center study of apatinib for eligible patients with advanced biliary tract carcinoma after the first-line treatment failure. A total of 55 patients is planned for enrollment. The time for enrollment is from Nov 2017 to Nov 2020, the the follow-up will be ended …

gemcitabine
carcinoma
measurable disease
advanced biliary tract carcinoma
apatinib
  • 15 views
  • 26 Feb, 2022
  • 1 location
Study of TRIFLURIDINE/TIPIRACIL in Previously Treated Cholangiocarcinoma (MOCHA)

This is a multi-centre, open-label, single arm phase 2 study to assess the efficacy of TRIFLURIDINE/TIPIRACIL, in patients with advanced cholangiocarcinoma as measured by median progression-free survival (PFS). This study will enroll a total of 47 patients over a 12-month period, according to a two stage enrollment design. Nine patients …

gemcitabine
cancer
kidney function tests
liver metastasis
biliary tract cancer
  • 58 views
  • 01 Mar, 2022
  • 1 location
Programmed Death Ligand (PD-L1) Combined With Chemotherapy for Patients With BTC (KN035-BTC)

This is a randomized, open-label, parallel-group multi-center study of Phase 3 study to assess the efficacy and safety of KN035 compared to standard of care (SOC) Gemcitabine-based chemotherapies in the treatment of participants with previously untreated locally advanced or metastatic biliary tract cancer. The primary hypothesis of this study is …

systemic therapy
recurrent disease
cholangiocarcinoma
gemcitabine
cancer
  • 8 views
  • 14 Jul, 2022
  • 1 location
The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer

The extent of hepatic resection for gallbladder cancer can be done from a wedge resection to 4b/5 bisegmentectomy. This study aims to compare the recurrence rates and survival rates between wedge resection group and bisegmentectomy group. Patients with T2 or T3 gallbladder cancer on preoperative CT exam or patients who …

  • 32 views
  • 21 Jan, 2021
  • 1 location
Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

This research study is studying a combination of drugs as a possible treatment for Hepatocellular Carcinoma or Biliary Tract Cancer. The interventions involved in this study are: Durvalumab Tremelimumab Radiation Therapy

gemcitabine
cholangiocarcinoma
carcinoma
measurable disease
cancer
  • 23 views
  • 03 Mar, 2022
  • 1 location
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

This is a Phase 2 study to evaluate the efficacy, using objective response rate, of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous Tumor Infiltrating Lymphocytes (TIL) and high-dose aldesleukin in patients with locally advanced, recurrent, or metastatic biliary tract cancer. These are low-incidence cancers carry a poor …

absolute neutrophil count
gilbert's syndrome
carcinoma
cholangiocarcinoma
cancer
  • 28 views
  • 04 Jun, 2022
Comparing the Current Hydration Regimen for the ABC02 Chemotherapy Regimen Versus a Shorter Hydration

This is an open label study for any patients with a bile duct cancer or gallbladder cancer, who will be treated with gemcitabine and cisplatin chemotherapy (the ABC02 regime). Patients recruited onto this study will have a reduction of their hydration time and be given Akynzeo as an anti-sickness drug, …

renal function
gemcitabine
cholangiocarcinoma
carcinoma
cancer
  • 4 views
  • 24 Jul, 2022
  • 1 location