Urothelial Tract Cancer Clinical Trials

A listing of Urothelial Tract Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 12 clinical trials
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

This trial studies how well tucatinib works for solid tumors that make either more HER2 or a different type of HER2 than usual (HER2 alterations) The solid tumors studied in this trial have either spread to other parts of the body (metastatic) or cannot be removed completely with surgery (unresectable). …

mammogram
cancer chemotherapy
endocrine therapy
fulvestrant
trastuzumab
  • 27 views
  • 03 Jul, 2022
  • 60 locations
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

sarcoma
carcinoma
measurable disease
squamous cell carcinoma
line of therapy
  • 14 views
  • 15 Jun, 2022
  • 25 locations
Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)

The purpose of this research study is to determine the safety and efficacy of CPI-613 (devimistat) in the treatment of advanced biliary tract cancer when used in combination with standard of care chemotherapy (gemcitabine plus cisplatin) compared to gemcitabine plus cisplatin alone. This research study has two parts: In the …

biliary tract cancer
carcinoma
advanced biliary tract carcinoma
cisplatin/gemcitabine
adjuvant chemotherapy
  • 9 views
  • 04 Jun, 2022
  • 9 locations
Programmed Death Ligand (PD-L1) Combined With Chemotherapy for Patients With BTC (KN035-BTC)

This is a randomized, open-label, parallel-group multi-center study of Phase 3 study to assess the efficacy and safety of KN035 compared to standard of care (SOC) Gemcitabine-based chemotherapies in the treatment of participants with previously untreated locally advanced or metastatic biliary tract cancer. The primary hypothesis of this study is …

recurrent disease
biliary tract cancer
oxaliplatin
metastatic biliary tract carcinoma
measurable disease
  • 8 views
  • 05 Jul, 2022
  • 1 location
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

This is a Phase 2 study to evaluate the efficacy, using objective response rate, of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous Tumor Infiltrating Lymphocytes (TIL) and high-dose aldesleukin in patients with locally advanced, recurrent, or metastatic biliary tract cancer. These are low-incidence cancers carry a poor …

biliary tract cancer
carcinoma
extrahepatic cholangiocarcinoma
metastasis
gallbladder cancer
  • 28 views
  • 04 Jun, 2022
PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study) (PLATON)

PLATON (Platform for Analyzing Targetable Mutations) is a prospective, multicentre, observational cohort study with biobanking. In a first approach PLATON's pilot-study assesses genomic profiling in gastrointestinal cancer therapy and the frequencies of targetable mutations including Tumor Mutational Burden (TMB) and Microsatellite Instability Status (MSI), performing Next-generation deep sequencing (NGS) using …

immunostimulants
carcinoma
pancreatic ductal adenocarcinoma
gastrointestinal cancer
adenocarcinoma
  • 0 views
  • 14 Jun, 2022
  • 29 locations
A Study of Patients Receiving High-Dose Rate Brachytherapy

Background One standard way of giving radiation is to combine external beam treatments with internal brachytherapy treatments, which involve short-range radiation therapy that gives a high dose of radiation directly to a cancer or to the area where cancer cells were removed. Brachytherapy is done by placing hollow implant device(s) …

carcinoma
ct scan
external beam radiation therapy
lung cancer
metastasis
  • 47 views
  • 01 Jul, 2022
  • 1 location
A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors (AMPLIFY-201)

This is a Phase 1 study to assess the safety and efficacy of ELI-002 immunotherapy (a lipid-conjugated immune-stimulatory oligonucleotide [Amph-CpG-7909] plus a mixture of lipid-conjugated peptide-based antigens [Amph-Peptides]) as adjuvant treatment of minimal residual disease (MRD) in subjects with KRAS/neuroblastoma ras viral oncogene homolog (NRAS) mutated PDAC or other solid …

KRAS
cancer chemotherapy
NRAS
  • 1 views
  • 03 Jul, 2022
  • 10 locations
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

Background Malignant mesothelioma is a malignancy arising from the mesothelial cells of the pleura, peritoneum, pericardium, or tunica vaginalis. Mesothelioma accounts for 0.10% of deaths annually in the United States. Malignant pleural mesothelioma is the most common of these, comprising of 80% of the cases with an annual incidence of …

pleural mesothelioma
malignant mesothelioma
carcinoma
adenocarcinoma
vaginalis
  • 15 views
  • 03 Jul, 2022
  • 1 location
Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

Background Recent advances in cancer research have led to new therapies to treat the disease. It is important to continue these advances and discover new ones. To do that, researchers need tissue samples from solid tumors. This study will collect such samples from people already scheduled to have a procedure …

white blood cell count
solid tumor
solid tumour
cancer
  • 18 views
  • 20 Jun, 2022
  • 1 location