Urothelial Tract Cancer Clinical Trials

A listing of Urothelial Tract Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 59 clinical trials
Featured trial
A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients with Advanced or Metastatic Urothelial Carcinoma (516-003)

This is a study involving an investigational (experimental) drug called sitravatinib, given in combination with the immunotherapy nivolumab (also known as OPDIVO®).  Sitravatinib is designed to block specific proteins that are thought to cause tumors to grow and to prevent growth of new blood vessels that help cancer tumors to …

carcinoma
urothelial carcinoma
platinum-based chemotherapy
advanced urothelial carcinoma
tumor cells
  • 86 views
  • 02 Jun, 2021
  • 1 location
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

This trial studies how well tucatinib works for solid tumors that make either more HER2 or a different type of HER2 than usual (HER2 alterations) The solid tumors studied in this trial have either spread to other parts of the body (metastatic) or cannot be removed completely with surgery (unresectable). …

mammogram
cancer chemotherapy
endocrine therapy
fulvestrant
trastuzumab
  • 27 views
  • 03 Jul, 2022
  • 60 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

NTRK
tyrosine
lung cancer
lung carcinoma
measurable disease
  • 162 views
  • 14 Jun, 2022
  • 129 locations
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

sarcoma
carcinoma
measurable disease
squamous cell carcinoma
line of therapy
  • 14 views
  • 15 Jun, 2022
  • 25 locations
Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors

A multicenter open-label phase 1/1b study to evaluate the safety and preliminary efficacy of SO-C101 as monotherapy and in combination with pembrolizumab in patients with selected advanced/metastatic solid tumors

cancer chemotherapy
biological factors
alopecia
measurable disease
pembrolizumab
  • 43 views
  • 30 Apr, 2022
  • 7 locations
Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

Investigators hypothesize that following first-line platinum based chemotherapy, rucaparib in combination with nivolumab, will improve progression-free survival and overall survival in BTC patients.

gall bladder
biliary tract cancer
rucaparib
adenocarcinoma
metastatic biliary tract carcinoma
  • 10 views
  • 22 Mar, 2022
  • 2 locations
Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients With Advanced Biliary Tract Cancer (BTC)

This research is studying the effect of the combination of how two study drugs (Nivolumab and DKN-01) works in people with advanced biliary tract cancer.

biliary tract cancer
radiofrequency ablation
advanced biliary tract carcinoma
extrahepatic cholangiocarcinoma
metastasis
  • 9 views
  • 21 Feb, 2022
A Study of RC48-ADC in Subjects With HER2 Overexpressed Metastatic Biliary Tract Cancer

This study will evaluate the efficacy and safety of intravenous RC48-ADC in patients with locally advanced or metastatic HER2 overexpressed biliary tract cancer who have failed first-line chemotherapy.

biliary tract cancer
metastatic biliary tract carcinoma
HER2
measurable disease
metastasis
  • 4 views
  • 03 Mar, 2022
  • 16 locations
Molecular Profiling of Advanced Biliary Tract Cancers (COMPASS-B-MUHC)

Biliary tract cancer (BTC) accounts for <1% of all cancers, but remains a highly fatal malignancy. Surgical resection is the only hope for cure, but most patients present with advanced disease when curative-intent surgery is not possible. The therapeutic options for patients with advanced disease are limited, primarily to chemotherapeutic …

biliary tract cancer
advanced biliary tract carcinoma
palliative care
biliary cancer
measurable disease
  • 0 views
  • 03 Mar, 2022
  • 1 location
A Study of the Efficacy and Safety of Chemotherapy Combined With Toripalimab in Advanced Biliary Tract Cancer

Target population: patients with advanced biliary tract cancer (including gallbladder carcinoma, intrahepatic and extrahepatic cholangiocarcinoma) . Primary objective: progression free survival (PFS)/ overall survival (OS) of first-line chemotherapy plus PD-1 antibody (Toripalimab) in patients with advanced biliary tract cancer. Secondary objectives: objective response rate (ORR) of first-line chemotherapy plus PD-1 …

  • 0 views
  • 22 Jan, 2021
  • 1 location