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Organ Transplant Clinical Trials

A listing of Organ Transplant medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (60) clinical trials

Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients

This clinical trial is a prospective single arm multi-institution study in children and young adults undergoing allogeneic or autologous hematopoietic stem cell transplantation who will receive early therapy with eculizumab to prevent TMA-associated MODS after transplantation. The purpose of this research study is to examine efficacy of complement blocker eculizumab ...


Reducing the Burden of Influenza After Solid-Organ Transplantation

Objectives: The primary objective of this study is to compare the immunogenicity of two novel vaccination strategies, consisting in vaccination with a HD influenza vaccine or an MF59a influenza vaccine, to the standard-dose non-adjuvanted vaccination (standard of care) in a population of SOT recipients. The main secondary objectives are to ...


Vaccines Immunogenicity in Renal Hepatic Cardiac or Pulmonary Transplanted Children

Thanks to improved surgical techniques, postoperative management and immunosuppressive therapies, an increasing number of children benefit from renal, hepatic, cardiac and pulmonary transplantation. Infection is a significant cause of mortality and morbidity in these patients, particularly due to vaccine-preventable diseases. Vaccination is one of the effective means of reducing infection-related ...

Phase N/A

Cell-Mediated Immunity Based Primary Prophylaxis for CMV Infection in Organ Transplant Recipients

Cytomegalovirus (CMV) disease is an important cause of morbidity in solid organ transplantation recipients and remains the most common opportunistic viral infection in these patients. Standard CMV prevention strategies include universal prophylaxis and pre-emptive therapy with viral load monitoring. However, neither of these strategies has been successful in eliminating CMV ...

Phase N/A

Goal of Open Lung Ventilation in Donors

Deceased organ donors are maintained on life support including mechanical ventilation during the time between brain death and organ procurement. The optimal mode of mechanical ventilation for deceased organ donors has not been definitively established. Since deceased organ donors may develop atelectasis leading to impaired oxygenation, an open lung protective ...

Phase N/A

Clinical Trial to Evaluate the Efficacy Pharmacokinetics (PK) Interactions and Safety of Dolutegravir Plus 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in HIV 1 Infected Solid Organ Transplant Patients

The aims of this study are to obtain pharmacokinetic data on interactions between dolutegravir (DTG) and immunosuppressant drugs (Cyclosporine A, Tacrolimus, Sirolimus and Mycophenolic acid) in solid organ transplant (SOT) recipients to provide proof of principle data that DTG plus 2 nucleosides (NUCs) is safe and effective in HIV-infected SOT ...


Trial to Evaluate the Safety and Effectiveness of the Portable Organ Care System (OCS ) Lung System for Recruiting Preserving and Assessing Non-Ideal Donor Lungs for Transplantation

Inclusion At least one of the following: Donor PaO2/FiO2 300 mmHg at the time of the offer; or Expected cross-clamp time > 6 hours for the second lung; or Donor after Cardiac Death (DCD donor); or Donor age 55 years old

Phase N/A

Retrospective Non-interventional Analysis of Opportunistic Infections in Immunocompromised and Frail Patients

The analysis of a cohort of consecutive non-selected patients from the Strasbourg University Hospital, and therefore representative of the real life, will allow better identifying the risk factors for these infections (by comparison with a cohort of patient with similar conditions of immunosuppression and no infection) and improving the diagnosis ...

Phase N/A

Vorinostat for Graft vs Host Disease Prevention in Children Adolescents and Young Adults Undergoing Unrelated Donor Blood and Marrow Transplantation

All subjects will undergo unrelated donor allogeneic blood and marrow transplant (BMT) according to local site institutional practice. The preparative regimen will depend upon the subject's underlying disease, previous therapy, and comorbidities. GVHD prophylaxis will consist of standard post-transplant immunosuppression, including tacrolimus and methotrexate. Vorinostat will be administered at 30, ...


Immunotherapy With Tacrolimus Resistant EBV CTL for Lymphoproliferative Disease After Solid Organ Transplant

This is a multi-centre, non-randomised, open label Phase 1 clinical trial of Advanced Therapy Investigational Medicinal Products (ATIMPs) in adult and paediatric (age 1-70 years) solid organ transplant recipients with histologically proven B-lineage EBV+ post-transplant lymphoproliferative disease (PTLD). The ATIMPs for this study are autologous EBV CTL transduced with the ...

Phase N/A