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Organ Transplant Clinical Trials

A listing of Organ Transplant medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (60) clinical trials

Goal of Open Lung Ventilation in Donors

Deceased organ donors are maintained on life support including mechanical ventilation during the time between brain death and organ procurement. The optimal mode of mechanical ventilation for deceased organ donors has not been definitively established. Since deceased organ donors may develop atelectasis leading to impaired oxygenation, an open lung protective ...

Phase N/A

Long-Term Follow-up of People Undergoing Hematopoietic Stem Cell Transplantation

Background Patients who survive more than 3 years after allogeneic hematopoietic stem cell transplantation (HCT) have a high probability of being cured from their underlying disease; however, mortality rates remain 4 to 9-fold higher than the general population for at least 30 years after HCT. The most common causes of ...

Phase N/A

Rituximab and LMP-Specific T-Cells in Treating Pediatric Solid Organ Recipients With EBV-Positive CD20-Positive Post-Transplant Lymphoproliferative Disorder

PRIMARY OBJECTIVES: I. To determine the feasibility of treating pediatric and young adult solid organ transplant recipients who have newly diagnosed, relapsed or refractory Epstein-Barr virus (EBV)-positive CD20-positive post-transplant lymphoproliferative disease (PTLD) with a novel T-cell therapeutic, allogeneic LMP1/LMP2-specific cytotoxic T-lymphocytes (third party latent membrane protein [(LMP]-)]-specific T cells), in ...


Clinical Trial to Evaluate the Efficacy Pharmacokinetics (PK) Interactions and Safety of Dolutegravir Plus 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in HIV 1 Infected Solid Organ Transplant Patients

The aims of this study are to obtain pharmacokinetic data on interactions between dolutegravir (DTG) and immunosuppressant drugs (Cyclosporine A, Tacrolimus, Sirolimus and Mycophenolic acid) in solid organ transplant (SOT) recipients to provide proof of principle data that DTG plus 2 nucleosides (NUCs) is safe and effective in HIV-infected SOT ...


HA-1 T TCR T Cell Immunotherapy for the Treating of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

PRIMARY OBJECTIVES: I. To evaluate the feasibility and safety of HA-1 T TCR T cell immunotherapy in approximately 12 children and adolescents and 12 adults with recurrent acute leukemia after allogeneic hematopoietic stem cell transplantation (HCT). SECONDARY OBJECTIVES: I. To determine the in vivo persistence of transferred HA-1 TCR T ...


Pharmacokinetic Study of Adoport (Tacrolimus) in Patients With de Novo Kidney Transplantation

Tacrolimus is a calcineurin inhibitor widely used for the prevention of allograft rejection in solid organ and bone marrow transplantation. It is characterized by a narrow therapeutic index and large inter-individual pharmacokinetic variability. Adoport is an immediate-release formulation of tacrolimus, to be administered twice daily. Because of a narrow therapeutic ...


CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Blood Cancer Undergoing Donor Stem Cell Transplant

PRIMARY OBJECTIVES: I. Establish the feasibility and safety of priming CMV immunity in donors by Triplex vaccination prior to peripheral blood stem cell (PBSC) harvest. SECONDARY OBJECTIVES: I. Examine if Triplex vaccination of hematopoietic stem cell transplant (HCT) donors has an impact on CMV events. OUTLINE Donors receive multi-peptide CMV-modified ...


Vorinostat for Graft vs Host Disease Prevention in Children Adolescents and Young Adults Undergoing Unrelated Donor Blood and Marrow Transplantation

All subjects will undergo unrelated donor allogeneic blood and marrow transplant (BMT) according to local site institutional practice. The preparative regimen will depend upon the subject's underlying disease, previous therapy, and comorbidities. GVHD prophylaxis will consist of standard post-transplant immunosuppression, including tacrolimus and methotrexate. Vorinostat will be administered at 30, ...


Haplo SCT vs Haplo-cord SCT for Patients With Hematological Disorders

Patients who have hematological disorders and will undergo haplo-identical donor stem cell transplantation (haplo SCT) are candidates of this trial. Participants will randomized into two arms: Arm A will undergo a typical haplo SCT, while Arm B will receive an co-infusion of an unrelated cord blood unit (haplo-cord SCT) in ...

Phase N/A

mHealth Family Self-Management

This innovative research will address a gap in the literature involving the evaluation of the impact of an individualized family-centered mHealth application to enhance daily post-discharge communication following pediatric transplant. This proposal lays the foundation for future research with myFAMI (self-management intervention) at multiple pediatric transplant centers and builds the ...

Phase N/A