Graft-Versus-Host Disease (GVHD) Clinical Trials

A listing of Graft-Versus-Host Disease (GVHD) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 240 clinical trials
Activity Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant

This open-label, single-arm, Phase II multi-center study will enroll approximately 42 subjects and investigate the activity, pharmacokinetics and safety of ruxolitinib added to the subject's immunosuppressive regimen among infants, children, and adolescents aged 28 days to <18 years old with either moderate to severe treatment-naive cGvHD or SR-cGvHD. Subjects will …

cancer
immunosuppressive agents
ruxolitinib
chronic graft versus host disease
myeloablative conditioning
  • 3 views
  • 26 Jul, 2021
  • 31 locations
Haplo vs. URD in AML

protocol before transplantation and a chemotherapy combined with immunosuppressive drugs after the transplantation to prevent graft-vs. host disease (GVHD). The patients receiving URD SCT will be treated

graft versus host disease
fludarabine
mycophenolate mofetil
hla-a
cyclophosphamide
  • 4 views
  • 23 Jan, 2021
  • 14 locations
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Pharmacogenomics (PG) offers the opportunity to individualize treatment according to patient genetic variations which influence activity of enzyme metabolizing or acting in the pathway of prescribed chemotherapy drugs. This add-on research aims to prospectively investigate variations in several candidate genes related to all types of chemotherapeutic drugs and TBI used …

b-cell acute lymphoblastic leukemia
remission
cancer
lymphoid leukemia
chemotherapy drug
  • 13 views
  • 23 Jan, 2021
  • 8 locations
Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

RATIONALE: Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow …

etoposide
cancer
thioguanine
lymphoid leukemia
mitoxantrone
  • 12 views
  • 23 Jan, 2021
  • 5 locations
Neihulizumab for Standard-Risk Acute Graft Versus Host Disease (GVHD)

This is a single-center Phase I study to determine the maximum tolerated dose and safety of Neihulizumab for the treatment of Minnesota standard-risk aGVHD. Patients undergoing allogeneic transplant with either a myeloablative or non-myeloablative conditioning regimen, and recipients of all donor sources will be enrolled to this trial.

  • 0 views
  • 25 Sep, 2021
  • 1 location
Donor Regulatory T Cells Infusion in Patients With Chronic Graft-versus-host Disease (GVHD)

The immune system has offensive and defensive capacities. In bone marrow transplantation, offensive cells in the donor grafts may attack host's organs, leading to a complication known as Graft versus Host Disease (GVDH). At present, patients receive steroid treatment to combat this tricky situation. Nevertheless, some patients do not respond …

  • 0 views
  • 07 May, 2021
  • 2 locations
Post Transplant Cyclophosphamide (PTCY) as Sole Graft Versus Host Disease (GVHD) Prophylaxis for Matched Allotransplant: CYRIC

Acute or chronic graft versus host disease is still the major complication of stem cells transplantation regarding morbidity and mortality. Recently, high dose cyclophosphamide utilization early after post-transplantation (day+ 3 and +4) not only for patients with HLA- haploidentical donor but also for patients with Human Leukocyte Antigen (HLA)-compatible donor, …

transplant conditioning
cell transplantation
mycophenolate
fludarabine
immunosuppressive agents
  • 6 views
  • 05 Mar, 2021
  • 1 location
Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function

The present project aims at investigating the role of MSC for the treatment of patients with Part 1: Steroid-refractory grade II-IV acute GVHD. Part 2: Poor graft function (PGF) Part 3: Low or falling donor T-cell chimerism after allogeneic HCT. This is a multicenter phase II study examining the feasibility …

tacrolimus
granulocyte colony stimulating factor
transplant conditioning
cyclosporine
acute graft-versus-host disease
  • 60 views
  • 07 May, 2021
  • 16 locations
To Compare the Efficacy of the Addition of Methotrexate (MTX) to Current Standard Acute Graft-versus-host Disease (GVHD) First-line Treatment With Corticosteroids

Phase III randomized double-blinded trial designed to compare the efficacy of the addition of MTX to current standard acute GVHD first-line treatment with corticosteroids. The protocol will use a novel endpoint for benchmarking interventions based on a composite primary endpoint of GVHD-free and corticosteroids-free survival. The primary endpoint of the …

graft versus host disease
platelet count
absolute neutrophil count
steroid therapy
serum pregnancy test
  • 0 views
  • 22 Jan, 2021
Extracorporeal Photopheresis for Acute Graft Versus Host Disease

The purpose of this research study is to evaluate the safety and feasibility of extracorporeal photopheresis (ECP) in the treatment of steroid-refractory acute graft-versus-host disease

graft versus host disease
hla matching
rash
extracorporeal photopheresis
chronic graft versus host disease
  • 12 views
  • 07 Nov, 2020
  • 1 location