Graft-Versus-Host Disease (GVHD) Clinical Trials

A listing of Graft-Versus-Host Disease (GVHD) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 39 clinical trials
RIC Regimen for Low- and Intermediate-risk MDS Receiving Haplo-HSCT

This study aimed to evaluate the efficacy of reduced intensity conditioning (RIC) regimen in low- and intermediate-risk myelodysplastic syndrome (MDS) patients who receive haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Haplo-HSCT is an effective treatment option for MDS patients who did not have identical sibling donor (ISD) or unrelated donor (URD). …

cyclophosphamide
fludarabine
thymoglobulin
transplant conditioning
antithymocyte globulin
  • 8 views
  • 22 Sep, 2021
  • 1 location
Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) Depletion for Patients With BMF

This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes.

paroxysmal nocturnal hemoglobinuria
stem cell transplantation
antibiotics
anemia
neutropenia
  • 17 views
  • 22 Sep, 2021
  • 1 location
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow transplantation (BMT). The procedure, however, is limited to children younger than the age of 16 because the risks are lower for children than for adults. The purpose of this study is to …

blood transfusion
iron
anemia
chest syndrome
osteonecrosis
  • 95 views
  • 22 Sep, 2021
  • 1 location
TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT

This trial studies how well radiation therapy techniques, volumetric modulated arc therapy (VMAT) and tomotherapy, work to reduce doses to the lung compared to standard total body irradiation methods to prevent pulmonary toxicities. Standard total body irradiation is limited in its ability to spare normal organs, with only the lung …

cyclophosphamide
cell transplantation
etoposide
total body irradiation
transplant conditioning
  • 0 views
  • 22 Sep, 2021
  • 1 location
Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ipilimumab when given together with decitabine in treating patients with myelodysplastic syndrome or acute myeloid leukemia that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as …

corticosteroids
ipilimumab
monoclonal antibodies
leukemia
blast cells
  • 187 views
  • 17 Sep, 2021
  • 6 locations
Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal …

cyclophosphamide
hepatitis b surface antigen
bone marrow procedure
human chorionic gonadotropin
leukemia
  • 2 views
  • 15 Sep, 2021
  • 1 location
Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus Host Disease

Background Chronic Graft Versus Host Disease (cGVHD) can occur after a person has had a stem cell or bone marrow transplant. In cGVHD, the donor cells attack the recipient s body. Researchers want to see if a drug called ibruntinib can block one of the proteins that lead to the …

budesonide
acute graft-versus-host disease
beclomethasone
ibrutinib
bone marrow transplant
  • 0 views
  • 12 Sep, 2021
  • 2 locations
Transplants With Unlicensed Preserved Cord Blood

Background Cord blood transplants can treat cancers and other diseases in children and adults. The U.S. Food and Drug Administration (FDA) requires cord blood to be collected and stored under certain safety standards. However, most available cord blood units were collected before the FDA set these standards. These units may …

cancer
  • 149 views
  • 21 Sep, 2021
  • 1 location
Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation

Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a procedure that transplants bone marrow cells (stem cells) from a matching donor into a recipient in order to allow the donor stem cells to produce cells that will attack the recipient s cancer cells. AlloHSCT is performed when chemotherapy, immunotherapy, or …

diffuse large b-cell lymphoma
lenalidomide
blood transfusion
hepatitis b surface antigen
monoclonal antibodies
  • 9 views
  • 19 Sep, 2021
  • 3 locations
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

Background Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell …

bone marrow failure syndromes
cyclophosphamide
allogeneic bone marrow transplantation
fludarabine
anemia
  • 52 views
  • 19 Sep, 2021
  • 2 locations