Graft-Versus-Host Disease (GVHD) Clinical Trials

A listing of Graft-Versus-Host Disease (GVHD) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 22 clinical trials
Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency

Background -DOCK8 deficiency is a genetic disorder that affects the immune system and can lead to severe recurrent infections and possible death from infections or certain types of cancers, including blood cancers. A stem cell transplant is a life-saving treatment for this condition. In this study we are evaluating the …

  • 1 views
  • 22 Jul, 2021
  • 1 location
Activity Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant

This open-label, single-arm, Phase II multi-center study will enroll approximately 42 subjects and investigate the activity, pharmacokinetics and safety of ruxolitinib added to the subject's immunosuppressive regimen among infants, children, and adolescents aged 28 days to <18 years old with either moderate to severe treatment-naive cGvHD or SR-cGvHD. Subjects will …

ruxolitinib
cancer
corticosteroids
chronic graft versus host disease
myeloablative conditioning
  • 3 views
  • 26 Jul, 2021
  • 31 locations
Study on the Treatment With Water-filtered Infrared-A (wIRA) Radiation in Patients With Morphea and Sclerotic Graft-versus-host Disease

the clinic, or Hydrosun 575home for home treatment) in patients with morphea or sclerotic GVHD (Graft-versus-host Disease). The purpose of the study is to determine whether wIRA irradiation can reduce

  • 0 views
  • 21 Jul, 2021
  • 2 locations
Detection of Graft Versus Host Disease With [18F]F-AraG

This is a single-center imaging study to determine utility of in vivo imaging with [18F]F-AraG to identify sites of Graft Versus Host Disease (GVHD) in patients highly suspected of having acute

corticosteroid therapy
acute graft-versus-host disease
steroid therapy
  • 14 views
  • 25 Jul, 2021
  • 1 location
High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

cells) capable of making a normal immune system. Transplant problems include graft versus host disease (GvHD) and graft rejection. With GvHD, donor cells attack the recipient s normal tissue

  • 3 views
  • 01 Aug, 2021
  • 1 location
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

mycophenolate mofetil is safe and effective in preventing severe graft-versus-host disease (GVHD) in most patients with hematologic malignancies undergoing transplantation of bone marrow from half-matched

hodgkin's disease
hematologic malignancy
leukemia
remission
hla-a
  • 25 views
  • 22 Jul, 2021
  • 2 locations
Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

destroys the donor s cells. Or donor immune cells attack the recipient s tissues, called graft-versus-host disease (GVHD). This is less likely when the recipient and donor have similar human leukocyte

hematologic malignancy
leukemia
doxorubicin
remission
hla-a
  • 23 views
  • 01 Aug, 2021
  • 2 locations
Fludarabine Based RIC for Bone Marrow Failure Syndromes

This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplastic anemia (AA) and Inherited bone marrow failure (iBMF) syndromes undergoing Matched related donor bone marrow transplant (MRD-BMT).

  • 0 views
  • 23 Jul, 2021
  • 1 location
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow transplantation (BMT). The procedure, however, is limited to children younger than the age of 16 because the risks are lower for children than for adults. The purpose of this study is to …

vaso-occlusive crisis
thalassemia
hydroxyurea
anemia
immunosuppressive agents
  • 95 views
  • 28 Jul, 2021
  • 1 location
Recombinant Human Interleukin-7 to Promote T-Cell Recovery After Cord Blood Transplant

This phase I trial studies side effects and best dose of recombinant interleukin-7 in promoting immune cell recovery in patients with acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia, or myeloproliferative disease after a cord blood transplant. Umbilical cord blood is a source of blood-forming cells that can be used …

filgrastim
myeloproliferative disorder
granulocyte colony stimulating factor
myeloid leukemia
leukemia
  • 0 views
  • 31 Jul, 2021