Diabetes Mellitus Types I and II Clinical Trials

A listing of Diabetes Mellitus Types I and II medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 101 clinical trials
A Randomized Placebo Controlled Trial of the Effectiveness of Metformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE)

The overall objective of the EMERGE trial is to determine whether metformin + usual care, compared to placebo + usual care (introduced at the time of initial diagnosis of GDM), reduces a) the need for insulin use, or hyperglycemia (primary outcome measure); b) excessive maternal weight gain; c) maternal and …

oral glucose tolerance test
  • 26 May, 2022
  • 1 location
A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema (KALAHARI)

Part A of the study is conducted to select the THR-149 dose level. Part B of the study is conducted to assess the efficacy and safety of the selected dose level compared to aflibercept, up to Month 3. As from Month 3, in about half of the subjects, the effect …

diabetic macular edema
type 2 diabetes mellitus
  • 25 Apr, 2022
  • 48 locations
Technology-Supported Treatment of Sleep Apnea in Prediabetes (TECH)

Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular complications in this high-risk population. Sleep apnea is a highly common condition in prediabetes, but it has …

  • 29 Apr, 2022
  • 1 location
Evaluation of the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects With Type 2 Diabetes on Insulin Therapy (REVITALIZE 1)

The Revita® system is being investigated to assess the efficacy of DMR versus Sham on improvement in Glycemic, Hepatic and Cardiovascular endpoints for patients with Type 2 Diabetes who are inadequately controlled with insulin therapy. The purpose of this study is to demonstrate the efficacy and safety of the Fractyl …

glycosylated hemoglobin
body mass index
hemoglobin a1c
  • 26 Apr, 2022
  • 18 locations
Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

This study will evaluate the safety and efficacy of ertugliflozin (MK-8835) in pediatric participants with T2DM on metformin with/without insulin. The primary hypothesis of the study is that the addition of ertugliflozin reduces hemoglobin A1C (HbA1C) more than the addition of placebo after 24 weeks of treatment.

body mass index
type 2 diabetes mellitus
hemoglobin a1c
  • 16 May, 2022
  • 74 locations
Eversense® Non-adjunctive Use Post Approval Study (NA-PAS)

This is a non-blinded, prospective, multi-center, single arm longitudinal cohort study (patient serving as their own control), to evaluate the effectiveness of diabetes with the Eversense CGM System non-adjunctively compared to self-monitoring of blood glucose (SMBG) using a blood glucose (BG) meter in participants with either Type 1 or Type …

self-monitoring of blood glucose
  • 09 May, 2022
  • 13 locations
Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA INTREPID)

The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in diabetic patients. Despite use of powerful antibiotics prescribed over a long period of time, many diabetic patients remain at …

diabetic foot
oral hypoglycemic
a hemoglobin
hypoglycemic agents
  • 24 May, 2022
  • 25 locations
Personalized Responses to Dietary Composition Trial 3

The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and controlled dietary intervention, for the purpose of …

nutrition education
body mass index
Accepts healthy volunteers
  • 24 Apr, 2022
  • 2 locations
Harambee: Integrated Community-based HIV/NCD Care & Microfinance Groups in Kenya

The objective of this project is to demonstrate the effectiveness and longer-term sustainability of a differentiated care delivery model for improving HIV treatment outcomes. The central hypothesis is that the integration of community-based HIV and NCD care with group microfinance will improve retention in care and rates of viral suppression …

hemoglobin a1c
  • 10 May, 2022
  • 1 location
New Heart Imaging Techniques to Evaluate Possible Heart Disease

Background Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions that lead to heart attacks. …

heart disease
ct scan
  • 14 May, 2022
  • 1 location