Common Variable Immunodeficiency (CVID) Clinical Trials

A listing of Common Variable Immunodeficiency (CVID) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 12 clinical trials
Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease (ABCVILD)

There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked

serum igg
immunodeficiency
immune globulin
interstitial lung disease
lung biopsy
  • 8 views
  • 07 Oct, 2022
  • 1 location
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Background Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems. Objective To see if allogeneic blood or bone marrow transplant is safe and effective in …

anesthesia
autoimmune disease
lymphoproliferative disorder
antibiotics
myeloablative conditioning
  • 511 views
  • 23 Oct, 2022
  • 2 locations
Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

Background Blood stem cells in the bone marrow make all the cells to normally defend a body against disease. Allogeneic blood or marrow transplant is when these stem cells are transferred from one person to another. Researchers think this treatment can provide a new, healthy immune system to correct T-cell …

hemolysis
anesthesia
lymphoproliferative disorder
oxygen saturation
cell transplantation
  • 138 views
  • 25 Oct, 2022
  • 2 locations
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.

langerhans cell histiocytosis
lymphoproliferative disorder
alemtuzumab
chediak-higashi syndrome
omenn's syndrome
  • 313 views
  • 29 Apr, 2022
  • 1 location
Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

granulocyte colony stimulating factor
hsct
filgrastim
alemtuzumab
stem cell transplantation
  • 125 views
  • 11 May, 2022
  • 1 location
Undetectable IgE as a Sentinel Biomarker for Humoral Immunodeficiency

This study is trying to find out if an undetectable serum immunoglobulin E (IgE) is a biomarker, or early sign of, the development of immune deficiency.

Accepts healthy volunteers
serum ige
immune globulin
immunoglobulins
  • 18 views
  • 24 May, 2022
  • 1 location
Natural History of Bronchiectasis

Background Bronchiectasis is a disease characterized by airways that are inflamed, abnormally dilated, and chronically infected. Individuals with bronchiectasis have a history of chronic and recurring respiratory infections. Depending on the underlying cause, these infections may involve the entire respiratory tract, resulting in sinus, ear, and lung disease. Bronchiectasis continues …

ct scan
cystic fibrosis
pulmonary function tests
genetic tests
genetic testing
  • 491 views
  • 21 Oct, 2022
  • 1 location
Studies of Immune Regulation in Patients With Common Variable Immunodeficiency and Related Humoral Immunodeficiency Syndromes

This study will explore the cause of immunodeficiency in common variable immunodeficiency (CVI) and other related immunodeficiency syndromes-IgA deficiency, hyper IgM syndrome, thymoma and agammaglobulinemia, hypogammaglobulinemia associated with Epstein-Barr infection, and others to better focus on how to correct the underlying defect. Patients with CVI and their family members may …

malabsorption
pulmonary function tests
agammaglobulinemia
genetic tests
blood test
  • 669 views
  • 25 Oct, 2022
  • 1 location
COVID-19 Vaccine Responses in PIDD Subjects

The goal of our study is to assess the cellular immune responses of participants with antibody deficiency disease before and after immunization with SARS-CoV-2 mRNA vaccines.

genetic testing
genetic tests
Accepts healthy volunteers
replacement therapy
immune globulin
  • 0 views
  • 20 Apr, 2022
  • 3 locations
Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? - A Prospective Observational Fatigue Trial (FatIgG)

The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration <7.0g/L) is a treatable cause of fatigue in people with MS: The primary objective is to prove the link between hypogammaglobulinemia and fatigue in patients with multiple sclerosis. The secondary objective is to show that fatigue is mediated via frequent …

  • 0 views
  • 14 Oct, 2022