Common Variable Immunodeficiency (CVID) Clinical Trials

A listing of Common Variable Immunodeficiency (CVID) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 11 clinical trials
Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease (ABCVILD)

There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked

serum igg
interstitial lung disease
lung biopsy
immune globulin
immunodeficiency
  • 8 views
  • 27 May, 2022
  • 1 location
Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

Background Blood stem cells in the bone marrow make all the cells to normally defend a body against disease. Allogeneic blood or marrow transplant is when these stem cells are transferred from one person to another. Researchers think this treatment can provide a new, healthy immune system to correct T-cell …

urine tests
graft versus host disease
x-rays
anemia
busulfan
  • 138 views
  • 26 Jul, 2022
  • 2 locations
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Background Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems. Objective To see if allogeneic blood or bone marrow transplant is safe and effective in …

urine tests
graft versus host disease
x-rays
hematologic malignancy
busulfan
  • 511 views
  • 11 Aug, 2022
  • 2 locations
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.

chediak-higashi syndrome
melphalan
fludarabine
stem cell transplantation
busulfan
  • 313 views
  • 29 Apr, 2022
  • 1 location
Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

immunosuppressive therapy
immune suppression
immunosuppressants
fludarabine
stem cell transplantation
  • 125 views
  • 11 May, 2022
  • 1 location
Undetectable IgE as a Sentinel Biomarker for Humoral Immunodeficiency

This study is trying to find out if an undetectable serum immunoglobulin E (IgE) is a biomarker, or early sign of, the development of immune deficiency.

serum ige
immunoglobulins
immune globulin
Accepts healthy volunteers
  • 18 views
  • 24 May, 2022
  • 1 location
Natural History of Bronchiectasis

Background Bronchiectasis is a disease characterized by airways that are inflamed, abnormally dilated, and chronically infected. Individuals with bronchiectasis have a history of chronic and recurring respiratory infections. Depending on the underlying cause, these infections may involve the entire respiratory tract, resulting in sinus, ear, and lung disease. Bronchiectasis continues …

lung disease
Accepts healthy volunteers
x-rays
pulmonary function tests
genetic testing
  • 491 views
  • 21 Jul, 2022
  • 1 location
Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes

This study will explore the cause of immunodeficiency in common variable immunodeficiency (CVI) and other related immunodeficiency syndromes-IgA deficiency, hyper IgM syndrome, thymoma and agammaglobulinemia, hypogammaglobulinemia associated with Epstein-Barr infection, and others to better focus on how to correct the underlying defect. Patients with CVI and their family members may …

x-rays
pulmonary function tests
agammaglobulinemia
malabsorption
genetic tests
  • 664 views
  • 26 Jul, 2022
  • 1 location
COVID-19 Vaccine Responses in PIDD Subjects

The goal of our study is to assess the cellular immune responses of participants with antibody deficiency disease before and after immunization with SARS-CoV-2 mRNA vaccines.

Accepts healthy volunteers
genetic testing
immune globulin
genetic tests
replacement therapy
  • 0 views
  • 20 Apr, 2022
  • 3 locations
New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies

Primary immune deficiencies (PID) are a group of chronic diseases characterized by recurrent infections. Apart from recurrent infections, in some of PIDs autoimmunity, allergy or malignancy could be accompanied to the diseases. Recently, the advanced sequencing technologies have led to the identification of a growing number of novel PIDs including …

  • 42 views
  • 25 Jan, 2021
  • 1 location