Lung Injury Clinical Trials

A listing of Lung Injury medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 231 clinical trials
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BPD Saturation TARgeting

Bronchopulmonary dysplasia (BPD), or chronic lung disease of prematurity, affects nearly half of extremely preterm infants.This study evaluates the use of supplemental oxygen to manage infants with established BPD. Participants will be randomly placed in either a higher oxygen saturation group or a lower oxygen saturation target group.

chronic lung disease
pulmonary disease
prematurity
severe bronchopulmonary dysplasia
premature birth
  • 0 views
  • 24 May, 2021
  • 3 locations
None
Human Mesenchymal Stem Cells For Bronchopulmonary Dysplasia

This study is an open-label, single-center, dose escalation study to evaluate of safety and efficacy of human umbilical cord -derived mesenchymal stem cells (hUC-MSCs) in premature infants for moderate and severe Bronchopulmonary DysplasiaBPD.

prematurity
severe bronchopulmonary dysplasia
premature birth
  • 9 views
  • 22 Jan, 2021
  • 1 location
None
Safety of Sildenafil in Premature Infants

Describe the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil. Funding Source - FDA OOPD.

prematurity
intermittent positive pressure ventilation
premature birth
  • 18 views
  • 14 Nov, 2021
  • 21 locations
None
Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants

The purpose of this study is to evaluate long-term safety and efficacy outcomes following previously administered short-term exposure to SHP607, as compared to a standard neonatal care group.

prematurity
premature birth
  • 0 views
  • 25 Sep, 2021
  • 7 locations
None
Work of Breathing in Premature Infants at Discharge

The purpose of this study is to compare how premature infants who required oxygen for at least 28 days during their time in the NICU (Neonatal Intensive Care Unit) breathe at discharge compared to premature infants who did not require oxygen for at least 28 days during their time in …

  • 0 views
  • 16 Aug, 2021
  • 1 location
None
Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure. The central hypothesis of this study is that silicosis cases may currently be going undetected. The long-term goal of this research is to determine …

  • 0 views
  • 25 Jan, 2021
None
Effect of Autologous Cord Blood Mononuclear Cells for Prevention of Bronchopulmonary Dysplasia in Extremely Preterm Neonates

This is the first and largest randomized, controlled, blinded trial that evaluates the efficacy of autologous cord blood mononuclear cells infusion as a prevention therapy for BPD. The results of this trial will provide valuable clinical evidence for recommendations on the management of BPD in extremely preterm infants. In this …

  • 0 views
  • 27 Nov, 2021
  • 2 locations
None
Risk Factors of Radiation Pneumonitis

A prospective observational study to evaluate clinical, dosimetrical, functional, and biological factors in predicting radiation pneumonitis.

  • 0 views
  • 07 Nov, 2020
  • 1 location
None
Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia

Multiple factors contribute to growth failure in infants with BPD, including poor nutrient stores, inadequate intake, increased losses, and increased needs. Furthermore, compared to infants without BPD, those with BPD have increased resting metabolic rates and energy expenditure. Growth deficits manifest as lower weight, length, and head circumference, as well …

prematurity
severe bronchopulmonary dysplasia
very low birth weight
zinc
  • 4 views
  • 26 Jan, 2021
  • 2 locations
None
A Cohort Study of the Intestinal Microbiota of Premature Infants

Premature infants are at risk for a variety of diseases, the investigators would like to learn more about why some premature babies are at higher risk and some are protected from these diseases. Scientists at UC Davis and other universities have developed new ways to measure the bacteria and a …

prematurity
necrotizing enterocolitis
small molecules
premature birth
  • 0 views
  • 12 Jun, 2021
  • 1 location