Lung Injury Clinical Trials

A listing of Lung Injury medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 226 clinical trials
Study on the Use of Sarilumab in Patients With COVID-19 Infection

Sarilumab is an anti-interleukin-6 human monoclonal antibody, such as tocilizumab, which is administered subcutaneously every two weeks for the treatment of moderate to severe active rheumatoid arthritis in adult patients. Despite the effectiveness reported for tocilizumab in the recently published experiences, the need to rapidly find alternative therapies to manage …

  • 0 views
  • 26 Jul, 2021
  • 1 location
Intravenous L-Citrulline to Delay and Potentially Prevent the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19 (SARS-CoV-2) Illness

Prospective, Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Intravenous L-Citrulline (Turnobi) to Delay and Potentially Prevent the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients with COVID-19 (SARS-CoV2) Illness. To evaluate safety and efficacy of a bolus loading dose and continuous intravenous infusion of L-Citrulline compared …

  • 0 views
  • 15 Sep, 2021
  • 1 location
Nutrition and Exercise in Critical Illness

This study proposes a novel early intervention combining Intravenous (IV) amino acids plus in-bed cycle ergometry exercise to improve physical outcomes in critically ill patients. The investigators hypothesize that this innovative approach will improve short-term physical functioning outcomes (primary outcome), as well as amino acid metabolism, body composition, and patient-reported …

mechanical ventilation
critical illness
  • 38 views
  • 12 Sep, 2021
  • 6 locations
Assessment of Regional Lung Ventilation Distribution During Supraglottic and Subglottic Jet Ventilation by EIT.

Objective: To estimate regional lung volume changes by electrical impedance tomography (EIT) during supra- and subglottic jet ventilation via the jet laryngoscope and LaserJet catheter for performing laryngotracheal surgery. Design: A monocentric, prospective, randomized study. Patients: Patients who require elective micro laryngo-tracheal surgery under jet ventilation. Interventions: Patients undergoing elective …

  • 0 views
  • 10 Sep, 2021
  • 1 location
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies …

positive end expiratory pressure
chronic lung disease
assisted ventilation
mechanical ventilation
  • 0 views
  • 29 Aug, 2021
  • 10 locations
Efficacy and Safety Study of BDB-001 in Severe COVID-19 With ALI/ARDS

This multi-center, open, randomized study will evaluate the efficacy and safety of BDB-001 injection in severe COVID-19 with severe pneumonia, or acute lung injury/acute respiratory distress

acute respiratory distress
FIO2
respiratory distress
oximetry
pao2
  • 91 views
  • 17 Feb, 2021
  • 11 locations
Pulmonary Function Using Non-invasive Forced Oscillometry

The purpose of this observational study is to measure pulmonary function in term and preterm infants with and without pulmonary disease including respiratory distress syndrome, bronchopulmonary dysplasia, transient tachypnea of the newborn, meconium aspiration syndrome, and response to treatments given to newborn infants with lung diseases using a non-invasive airway …

respiratory distress
transient tachypnea of newborn
continuous positive airway pressure
bronchopulmonary dysplasia
pulmonary disease
  • 53 views
  • 11 May, 2021
  • 1 location
Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON)

exists over the net effects of preserved early spontaneous breathing activity with regard to ventilator-associated lung injury (VALI). In fact, by taking advantage of the potential improvement in

  • 0 views
  • 15 Feb, 2021
  • 1 location
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19)

This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a …

mechanical ventilation
FIO2
positive end expiratory pressure
assisted breathing
acute respiratory distress
  • 17 views
  • 23 Jul, 2021
  • 23 locations
SEvoflurane for Sedation in ARds

This study evaluates whether a sedation with inhaled sevoflurane will decrease mortality and increase time off the ventilator at 28 days in patients with acute respiratory distress syndrome (ARDS). Half of the patients will receive inhaled sedation with sevoflurane and the other half will receive intravenous sedation with propofol.

sevoflurane
respiratory failure
respiratory symptom
positive end expiratory pressure
pao2
  • 0 views
  • 04 Sep, 2021
  • 24 locations