Lung Injury Clinical Trials

A listing of Lung Injury medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 77 clinical trials
An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study (PRIME-AIR)

Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of hospitalization. The objective of the study is to develop and implement perioperative strategies to eliminate PPCs in abdominal surgery, …

  • 21 Jul, 2022
  • 10 locations
A Phase II Study in Patients With Moderate to Severe ARDS Due to COVID-19

This is a Phase II multi-center, double-blind, placebo-controlled, randomized study in Patients with moderate to severe lung injury due to COVID-19 or other potential viral and bacterial

  • 22 Jul, 2022
  • 2 locations
Effect of EIT-guided PEEP Titration on the Prognosis of Patients With Moderate to Severe ARDS

-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for

  • 27 Jul, 2022
  • 1 location
Prediction of Adverse Outcome Using Fetal MRI in Pregnancies at Risk of Preterm Birth

1.4% of babies have a very premature birth (PTB) (less than 32 weeks of pregnancy). This can result in severe life-long complications including cerebral palsy, learning and behavioural difficulties and breathing problems. This has significant cost implications for the NHS, education services and immeasurable human costs for the child and …

Accepts healthy volunteers
  • 22 Apr, 2022
First-In-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALT-100

ALT-100 is a monoclonal antibody developed by Aqualung Therapeutics Corp. as a treatment for Acute Respiratory Distress Syndrome (ARDS). ARDS can occur as a serious complication in patients with respiratory infections such as COVID-19 and Influenza or have acquired trauma to their lungs. 32 healthy male or female participants between …

Accepts healthy volunteers
  • 20 Jul, 2022
  • 1 location
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial). (POLAR)

Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies …

chronic lung disease
positive end expiratory pressure
mechanical ventilation
assisted ventilation
  • 14 Jul, 2022
  • 7 locations
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19) (CAVIARDS)

This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a …

positive end expiratory pressure
acute respiratory distress
assisted breathing
  • 09 Jul, 2022
  • 26 locations
Tuberculosis (TB) Aftermath

TB Aftermath will compare effectiveness, cost-effectiveness and feasibility of two ACF strategies that are presently being considered by the RNTCP for detecting recurrent TB and provide evidence needed to implement and scale the preferred intervention. The proposed study will address this gap, through the following specific aims: Primary Aim 1: …

Accepts healthy volunteers
  • 12 May, 2022
  • 1 location
Inhibition of Plasma Kallikrein as a New Therapy for Lung Injury

Phase 1 study investigating safety of lanadelumab administration to patients with lung injury

  • 16 May, 2022
  • 1 location
Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis

Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis

chest ct scan
  • 07 Apr, 2022
  • 1 location