Nasal Obstruction Clinical Trials

A listing of Nasal Obstruction medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 7 clinical trials
Featured trial
Dupilumab in CRSsNP (Liberty CRSsNP ORION)  

Primary Objective: Part A and B: To evaluate the efficacy of dupilumab as assessed by the reduction at Week 24 in sinus opacification on computerized tomography (CT) scan and sinus total symptom score (sTSS) compared to placebo Secondary Objectives: Part A To evaluate the efficacy of dupilumab as assessed by …

nasal congestion
  • 31 Jan, 2023
  • 8 locations
Microbiota Transfer for Chronic Rhinosinusitis (SNMT)

biofilms, chronic inflammation and possibly an unhealthy population of sinus microbes (or microbiota). Symptoms include nasal obstruction and discharge, facial pain, loss of smell and sleep disturbance

facial pain
chronic sinusitis
Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps (EMRESSECRS)

Functional endoscopic sinus surgery (FESS) is the pimary surgical treatment of CRS, characterized with the preservation of nasal structure and function.But the control of disease by surgery has been unsatisfactory. Recent studies have shown that patients with recurrent CRSwNP (usually with severe eosinophilic inflammation), more radical surgery may be more …

other disease
  • 04 Oct, 2022
  • 1 location
Impact of Respiratory Physiotherapy in Children With Bronchiolitis in the First Two Years of Life

This study aims to evaluate the recovery of children with bronchiolitis with and without physical therapy treatments. The experimental group will receive educational information and 5 sessions of physiotherapy with the same protocol, at home or in physical therapy office. The control group will only be evaluated. For both the …

  • 10 Oct, 2022
Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP): a Randomized Double Blind Placebo Controlled Phase II Study

The overarching objective of this study is to determine the clinical effectiveness of dupilumab for the treatment of CRS that includes several potential disease endotypes with the exclusion of the nasal polyp cluster that has previously been determined. The additional information gained from secondary and exploratory outcomes will help provide …

nasal polyp
antibiotic therapy
eosinophil count
  • 28 Oct, 2022
  • 1 location
Dupilumab in the Treatment of Severe Uncontrolled CRSwNP: a Multicentre Observational Real-life Study (DUPIREAL) (DUPIREAL)

changes in nasal symptoms, olfactory function and nasal obstruction the assessment of the patients' quality of life the recording of major and minor complications the

  • 07 Oct, 2022
  • 16 locations
A Natural History Study of Children and Adults With Olfactory Neuroblastoma

Background Olfactory neuroblastoma (ONB) is a rare cancer. It grows from tissue in the upper part of the nose cavity, related to the sense of smell and can affect a person s sense of smell. Researchers want to better understand the health problems of people with ONB. This may help …

  • 21 Oct, 2022
  • 1 location