Idiopathic Pulmonary Fibrosis Clinical Trials

We anticipate a number of observational studies will be developed from the data collected in the IPF-PRO registry. All planned analyses will be performed by the DCRI statistical team. Planning of the analyses will be done as a coordinated effort between the teams at the DCRI and Boehringer Ingelheim (refer ...

Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry

To assess efficacy and safety of concomitant treatment with nintedanib and sildenafil in IPF patients with advanced lung function impairment.

Winthrop University Hospital Clinical Trials Center is seeking volunteers who have been diagnosed with Idiopathic Pulmonary Fibrosis, a condition which decreases lung function. This study is testing an investigational medication to see if it is safe and effective. Eligible participants will receive study related medical care and study medication at ...

To evaluate the change in 6MWD after 8 weeks of treatment with iNO vs. 8 weeks on placebo as measured by 6MWT (6 minute walk test).

DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers want to see ...

Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive disease that occurs primarily in older individuals, 55 to 75 years of age, with a median survival of approximately 3 years from time of diagnosis. At present, there are no effective treatments for patients with IPF. Levels of apolipoprotein A-I (apoA-I) have ...

Interstitial lung disease (ILD) is characterised by inflammation and scarring of the lung and is the leading cause of death in patients with systemic sclerosis, and contributes significantly to morbidity and mortality in many other connective tissue diseases (CTDs) such as polymyositis/dermatomyositis and mixed connective tissue disease. When ILD is ...

The primary objective of this study is to evaluate the ventilation defect percent (VDP), apparent diffusion coefficient (ADC) and/or the signal-to-noise ratio (SNR) obtained by analysis of hyperpolarized 129Xe MRI at one or more time-points (over time in the absence of therapeutic intervention or following clinically indicated therapy) in healthy ...

Systemic sclerosis (SSc) is a chronic multisystem autoimmune connective tissue disease for which the etiology remains unknown. The prevalence for SSc is between 19-75 cases per 100,000 and it is more frequent in women, with a peak occurrence in the 4th or 5th decade of life. Morbidity and Mortality in ...