Leukemia (Pediatric) Clinical Trials

A listing of Leukemia (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 10 clinical trials
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The Axcelsius Study: A Study of ONO-7475 in Patients with Acute Leukemias

What is the Axcelsius study? The Axcelsius study is a clinical research study being conducted to determine the safety and tolerability of the study drug called ONO-7475. ONO-7475 has been tested in AML patients and was confirmed safe and tolerable at a dose to be used in the study. Previous …

venetoclax
blast cells
induction chemotherapy
remission
cancer
  • 0 views
  • 23 Jul, 2021
  • 3 locations
A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients

This study will explore 2 different doses of inotuzumab ozogamicin including the dose that is approved and a lower dose. The main purpose of this study is to evaluate whether a dose of inotuzumab ozogamicin, lower than the approved dose, could be recommended for adult patient with relapsed or refractory …

serum bilirubin level
induction chemotherapy
blast cells
lymphoma
refractory acute lymphoblastic leukemia
  • 178 views
  • 24 Jul, 2021
  • 80 locations
A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Haploidentical Hematopoietic Cell Transplantation

This research study is is studying cytokine induced memory-like natural killer (CIML NK) cells plus IL-2 in Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Myeloproliferative Neoplasms (MPN.

myeloproliferative disorder
cell transplantation
blast cells
myeloid leukemia
prednisone
  • 4 views
  • 01 Aug, 2021
Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocyte Leukemia

Background Chronic lymphocytic leukemia (CLL) is a blood cancer. Recombinant human interleukin 15 (IL-15) is a manmade protein. Obinutuzumab is a protein made to deactivate cancer cells. Researchers want to see if treating people with CLL with both proteins improves their outcomes. Objectives To find the safe dose of IL-15 …

thrombocytopenia
chronic lymphocytic leukemia
lymphoma
anemia
lymphoid leukemia
  • 0 views
  • 02 Aug, 2021
  • 1 location
Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children

This study evaluates the use of carfilzomib in combination with cyclophosphamide and etoposide for children with relapsed/refractory solid tumors or leukemia. The medications cyclophosphamide and etoposide are standard drugs often used together for the treatment of cancer in children with solid tumors or leukemia. Carfilzomib is FDA (Food and Drug …

etoposide
filgrastim
graft versus host disease
blast cells
lymphoma
  • 0 views
  • 20 Jul, 2021
  • 9 locations
Umbilical Cord Blood-Derived Natural Killer Cells Elotuzumab Lenalidomide and High Dose Melphalan Followed by Stem Cell Transplant in Treating Patients With Multiple Myeloma

This phase II trial studies the side effects and best dose of umbilical cord blood-derived natural killer cells when given together with elotuzumab, lenalidomide, and high dose melphalan before autologous stem cell transplant and to see how well they work in treating patients with multiple myeloma. Before transplant, stem cells …

elotuzumab
ejection fraction
cancer
melphalan
lenalidomide
  • 28 views
  • 22 Jul, 2021
  • 1 location
Ibrutinib Fludarabine Phosphate Cyclophosphamide and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

This phase II trial studies how well ibrutinib, fludarabine phosphate, cyclophosphamide, and obinutuzumab work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work …

platelet count
monoclonal protein
lymphoma
cancer
monoclonal antibodies
  • 0 views
  • 29 Jul, 2021
  • 1 location
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

This randomized phase III trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus plantarum may help prevent the development of gastrointestinal graft versus host disease in children, adolescents, and young adults undergoing donor stem cell transplant.

cell transplantation
graft versus host disease
  • 13 views
  • 01 Aug, 2021
  • 28 locations
Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes

The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease …

cancer
acute leukemia
thrombocytopenia
myeloid leukemia
  • 3 views
  • 30 Jul, 2021
  • 1 location
Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing

Background Leukapheresis is a procedure to separate and collect white blood cells. It is the first step in a treatment called CAR (chimeric antigen receptor) T-cell therapy. CAR-T therapy may be offered to people when their cancer comes back. The collected T-cells are used to make a special version of …

white blood cells
flow cytometry
lymphoma
blood cell count
remission
  • 19 views
  • 01 Aug, 2021
  • 1 location