Coronary Artery Disease Clinical Trials

The treatment options this study will compare are: (1) Hybrid Coronary Revascularization [HCR] (a combination of surgery and catheter procedures to open up clogged heart arteries) and (2) Percutaneous Coronary Intervention [PCI] (catheter procedures alone to open up clogged heart arteries). There are no new or "experimental" procedures being tested ...

The purpose of this post-market feasibility study is to evaluate whether DyeVert Plus Contrast Reduction System use during standard angiography procedures involving the use of OCT result in contrast media (CM) volume savings without reducing image quality. The primary objective of this study is to evaluate the volume (percentage) of ...

This is a prospective, randomized one to one (1:1), multi-center trial designed to evaluate vessel preparation with Orbital Atherectomy (OA) compared to conventional balloon angioplasty technique prior to stent implantation for the treatment of severely calcified coronary artery lesions.  

This study will observe the continued performance of the Medtronic Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System in a real-world more-comer population.  

This is a study to assess the relationship between iFR and coronary stenosis. iFR safely and accurately quantifies stenosis severity in a wide range of lesions and may be helpful in assessing post PCI (percutaneous coronary intervention) physiology.

The study objective is to determine if the use of two or more arterial grafts in coronary artery bypass surgery (CABG) compared to a single arterial graft is associated with  improved survival. There is no "experimental" procedures being tested in this study. Cardiac surgeons use both arterial and vein grafts ...

The primary purpose of this study is to determine whether treatment with the Cobra PzF stent with 14 day Dual Anti-Platelet Therapy (DAPT) has a better safety profile compared to standard FDA approved Drug Eluting Stent plus 6-Month Dual Anti-Platelet Therapy in patients undergoing coronary intervention who also require oral ...

The objective of the HeartFlow ADVANCE Registry is to evaluate utility, clinical outcomes and resource utilization of FFRCT-guided evaluation in clinically stable, symptomatic patients with coronary artery disease (CAD) in order to further inform patients, health care providers, and other stakeholders about which technologies are most effective and efficient in ...

The purpose of this study is to evaluate the incremental benefit of Fractional Flow Reserve (FFR) derived from Coronary Computed Tomographic Angiography (CCTA) (CT-FFR) compared to CCTA with or without stress testing, using invasive FFR as the gold standard for patients with obstructive disease (> 30% and < 90% stenosis).  ...

The primary purpose of this study is to determine whether treatment with the Cobra PzF stent with 14 day Dual Anti-Platelet Therapy (DAPT) has a better safety profile compared to standard FDA approved Drug Eluting Stent plus 6-Month Dual Anti-Platelet Therapy in patients undergoing coronary intervention who also require oral ...