Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 727 clinical trials
The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 on Children With Rheumatic Diseases

The study aims to explore the therapeutic value and mechanism of Interleukin-2 on children with rheumatic diseases (Systemic Lupus Erythematosus, Primary Sjgren Syndrome, Juvenile Idiopathic Arthritis).

rheumatic diseases
arthritis
sjogren's syndrome
interleukin-2
lupus
  • 0 views
  • 26 Jan, 2021
  • 1 location
O-GlcNAcylation Role in the Pathophysiology of Systemic Lupus Erythematosus

This study aims at defining the role of O-GlcNAcylation is in the physiopathology of systemic lupus erythematosus (SLE). O-GlcNAcylation is a metabolic pathway potentially implicated in SLE with potential for the discovery of new therapeutic strategies.

lupus
  • 0 views
  • 26 Jan, 2021
  • 1 location
Immune Mediators and Metabolites to Stratify Systemic Lupus Erythematosus Patients at High Risk of Cardio Vascular Diseases

Accelerated atherosclerosis is an established complication of systemic autoimmune diseases, particularly SLE. Young female patients with SLE are more likely to develop myocardial infarction than matched healthy controls, and CVD is nowadays one of the most common causes of death (27%) in lupus patients. While traditional CV risk factors cannot …

  • 0 views
  • 19 Mar, 2021
  • 4 locations
Exploring the Efficacy and Safety of CS20AT04 (Allogenic Bone Marrow-Derived Stem Cell) in Systemic Lupus Erythematosus Patients

This is an open-label, one-arm single-center phase a study exploring the efficacy and safety of CS20AT04 (HLA-haplo Matched Allogenic Bone Marrow-Derived Stem Cells) in two subpopulation group of systemic lupus erythematosus patients - lupus nephritis and lupus cytopenia.

  • 0 views
  • 16 Apr, 2021
  • 1 location
Efficacy and Safety of Low-dose IL-2 in Patients With SLE: a Multicenter Randomised Placebo-controlled Trial

The management of active systemic lupus erythematosus (SLE) is challenging due to the heterogeneous nature of the disease and lack of specific treatment. Current treatment regimens mainly rely on corticosteroids and immunosuppressive agents which are associated with substantial adverse effects including various infections. Therefore, there is an unmet need for …

immunosuppressive agents
cyclophosphamide
mycophenolate
hydroxychloroquine
corticosteroids
  • 5 views
  • 24 Jan, 2021
  • 1 location
Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus

This study aims to investigate the feasibility and effectiveness of a remotely delivered psychological intervention for youth with cSLE. This intervention aims to teach participants skills in order to cope with fatigue, pain, and depressive symptoms--symptoms that commonly affect adolescents and young adults with lupus.

lupus
  • 0 views
  • 18 Mar, 2021
  • 2 locations
Pegtibatinase as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE)

Homocystinuria caused by Cystathionine Beta-Synthase (CBS) Deficiency is a rare autosomal-recessive metabolic condition characterized by an excess of homocysteine (Hcy) in the plasma, tissues and urine. It is due to reduced or absent activity of the CBS enzyme, and is also known as classical homocystinuria. The symptoms associated with homocystinuria …

  • 19 views
  • 12 Sep, 2021
  • 12 locations
Allogeneic Bone Marrow Mesenchymal Stem Cells for Patients With Interstitial Lung Disease (ILD) & Connective Tissue Disorders (CTD)

experimental, for Interstitial Lung Disease (ILD) associated with Connective Tissue Disorder (CTD).

lung disease
pulmonary disease
pneumonia
anca
conventional therapy
  • 273 views
  • 13 Jun, 2021
  • 1 location
Clinical Trial to Evaluate Efficacy and Safety of Dupilumab in Localized Scleroderma

The DupiMorph study evaluates the efficacy of Dupilumab in localized scleroderma patients. Dupilumab is approved in the US and EU for the treatment of moderate/severe atopic dermatitis and since 2018 in the US for severe asthma therapy.

  • 33 views
  • 24 Jan, 2021
  • 2 locations
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB Resorbable Implant Device

Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition. In Flanders, Dupuytren's disease was found to be present in 32% of the population over 50 years. In severe flexion contracture finger deformity due to Dupuytren's disease, functional loss of …

  • 0 views
  • 26 Jan, 2021
  • 1 location