Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 731 clinical trials
Subcutaneous Injections of Autologous ASC to Heal Digital Ulcers in Patients With Scleroderma.

Ischemic digital ulcers (DUs) are a frequent complication in systemic sclerosis with a major impact on hand function and quality of life. Digital injection of autologous cultured adipose-derived stromal constitutes a promising approach to treat scleroderma-induced refractory ischemic DUs where no alternative therapy is validated. The aim of this phase …

digital ulcer
scleroderma
follicle stimulating hormone
progressive systemic sclerosis
  • 0 views
  • 25 Jan, 2021
  • 6 locations
A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab & Rituximab or placebo.Patients in both groups will be on background MMF for the entirety …

rheumatism
diffuse cutaneous systemic sclerosis
immunosuppressive agents
MRSS
cancer
  • 29 views
  • 15 Sep, 2022
  • 1 location
Exercise Capacity of Patients With Dermatomyosis

Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown. The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.

dermatomyositis
weakness
myopathy
creatine kinase
muscle biopsy
  • 0 views
  • 19 Sep, 2021
  • 1 location
Safety, Tolerability and Pharmacodynamics of SYNB1353 in Healthy Adult Volunteers (HCU)

This is a Phase 1, double-blind (Sponsor-open), placebo-controlled, randomized, dose-escalation, inpatient study using a multiple-ascending dose (MAD) design to assess the safety, tolerability, and PD of SYNB1353 in HVs.

Accepts healthy volunteers
  • 0 views
  • 24 Jul, 2022
  • 1 location
Novel Form of Acquired Long QT Syndrome

The goal of this study is to determine whether anti-Ro/SSA antibodies are associated with acquired QT prolongation in subjects with connective tissue disease. The investigators will investigate

cytokines
rheumatism
prednisone
anti-ro antibody
acquired long qt syndrome
  • 4 views
  • 20 Apr, 2022
  • 1 location
Eltrombopag Combined With Low-dose Rituximab in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies

This prospective, open-label, nonrandomized, multicenter clinical trial aims at comparing the efficacy and safety of combined use of eltrombopag with low-dose rituximab vs. the best available therapy(BAT)in adult immune thrombocytopenia with autoantibodies fail (due to intolerance or resistance) to first-line treatment.

recombinant human thrombopoietin
platelet count
sjogren's syndrome
eltrombopag
thrombocytopenia
  • 0 views
  • 26 May, 2022
  • 1 location
Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies

This prospective, open-label, single-center, one-arm clinical trial aims at evaluating the efficacy and safety of avatrombopag in Chinese adult Immune Thrombocytopenia (ITP) patients with autoantibodies fail (due to intolerance or resistance) to eltrombopag or herombopag treatment.

recombinant human thrombopoietin
platelet count
sjogren's syndrome
eltrombopag
thrombocytopenia
  • 0 views
  • 21 Jul, 2022
  • 1 location
Effects of Personalized Training at Home Combining Endurance and Resistance in Patients Suffering From Marfan Syndrome

Marfan syndrome (MS) is an autosomal dominant genetic disorder caused by a mutation in the fibrillin-1 gene (FBN1) encoding the protein fibrillin-1. Fibrillin is the main component of microfibrils, elements found in all of the body's tissues, and this pathology is characterized by the multitude of its clinical manifestations. These …

  • 0 views
  • 18 Apr, 2021
  • 1 location
PRP for Treatment of Peyronie's Disease

The purpose of this study is to learn about the effects of Platelet-Rich Plasma (PRP) injection in men with Peyronie's Disease (PyD).

  • 84 views
  • 05 May, 2022
  • 1 location
Efficacy, Safety, and Tolerability, of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis

This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of up to 2 treatments of EN3835 vs placebo in participants with plantar fibromatosis.

  • 3 views
  • 11 May, 2022
  • 40 locations