Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 83 clinical trials
Safety Tolerability Pharmacokinetics and Therapeutic Efficacy of SAR441344 in Primary Sj gren's Syndrome (pSjS)

Primary Objective: To evaluate the therapeutic efficacy of one dose level of SAR441344 versus placebo over 12 weeks in adult patients with primary Sjgren's syndrome (pSjS), assessed by the change of the European League Against Rheumatism (EULAR) Sjgren's Syndrome Disease Activity Index (ESSDAI) Secondary Objectives: To evaluate the therapeutic efficacy …

  • 24 Sep, 2021
  • 33 locations
Long-Term Safety Study Of Tofacitinib In Patients With Juvenile Idiopathic Arthritis

Evaluate long-term safety and tolerability of tofacitinib in patients with JIA, who have previously participated in tofacitinib JIA studies.

treatment regimen
  • 22 Sep, 2021
  • 177 locations
Actis Total Hip System 2 Year Follow-up

Two-year (2 year) information regarding the performance of the commercially available Actis Total Hip System in order to obtain and evaluate the clinical outcomes on a series of cementless primary total hip arthroplasty (THA) and hemi-hip arthroplasty procedures using clinical, radiographic and device and procedure related adverse event assessments.

internal fixation
hip dislocation
joint reconstruction
  • 16 Sep, 2021
  • 10 locations
A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis

This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week corticosteroid (CS) taper regimen compared to placebo in combination with a 52-week CS taper regimen, as measured by the proportion of participants in sustained remission at Week …

  • 22 Sep, 2021
  • 313 locations
A Study of Potential Treatment-Responsive Biomarkers in Hunter Syndrome

This is an observational, Pre-phase 1 study of biomarkers in patients with mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome.

general anesthesia
ids gene
  • 12 Sep, 2021
  • 8 locations
A Study of DNL310 in Pediatric Participants With Hunter Syndrome

This is a multicenter, multiregional, open-label study to assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of DNL310, an investigational central nervous system (CNS)-penetrant enzyme replacement therapy (ERT), designed to treat both the peripheral and CNS manifestations of Mucopolysaccharidosis type II (MPS II; Hunter syndrome). The study has three cohorts:Cohort …

enzyme replacement therapy
iduronate 2-sulfatase
  • 12 Sep, 2021
  • 4 locations
Evaluation of Women With Endocrine and Reproductive-Related Conditions

This study was designed to allow inpatient and outpatient evaluation of women with a variety of reproductive and endocrine-related disorders for purposes of research and physician education. The evaluations may include ultrasound examinations, blood, saliva, and/or urine samples. In some cases, specific laboratory or X-ray studies will be performed to …

  • 19 Sep, 2021
  • 1 location
Tivanisiran for Dry Eye in Subjects With Sj gren's Syndrome

This study will examine the efficacy and safety of tivanisiran sodium eye drops versus vehicle after a 2-week run-in phase when dosed once daily for 3 months in subjects with signs and symptoms of dry eye disease (DED) due to Sjgren's Syndrome.

  • 18 Sep, 2021
  • 30 locations
A Study to Evaluate the Change in Disease State and Adverse Events in Adult Participants With Polymyalgia Rheumatica (PMR) Dependent on Glucocorticoid Treatment Receiving Subcutaneous Injections of ABBV-154

Polymyalgia rheumatica (PMR) is an inflammatory disease causing shoulder, hip, and neck pain and stiffness, in adults aged 50 years or older. This study evaluates how safe and effective ABBV-154 is in participants with glucocorticoid-dependent PMR. Adverse events and change in disease activity will be assessed. ABBV-154 is an investigational …

  • 23 Sep, 2021
  • 106 locations
A Pilot Study to Explore the Role of Gut Flora in Acne

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.

  • 12 Sep, 2021
  • 1 location