Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 130 clinical trials
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) (PROMISSE)

The PROMISSE Study is an observational study of 700 pregnant patients, enrolled at nine major clinical centers. The purpose of the study is 1) to determine whether certain proteins (called complement split products) that can injure healthy organs can be used to predict poor pregnancy outcome in patients with systemic …

antiangiogenic
fetal death
miscarriage
antiphospholipid syndrome
Accepts healthy volunteers
  • 349 views
  • 19 Sep, 2022
  • 4 locations
Studies of the Natural History of Rheumatic Disease in Minority Communities

This study will explore the causes of rheumatic diseases and why many of them affect certain minority communities more severely. Rheumatic diseases may cause joint pain, stiffness or swelling. Some can involve bones, muscles, tendons or ligaments. Some cause abnormalities of the immune system the body s defense against disease. …

x-rays
swelling
rheumatism
blood test
arthritis
  • 50 views
  • 18 Sep, 2022
  • 1 location
Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies

This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their cause and the immune system changes and medical problems associated with them. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability. Children or adults with polymyositis or …

connective tissue disease
x-rays
skin inflammation
rheumatism
urine tests
  • 166 views
  • 17 Sep, 2022
  • 4 locations
Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases

This study of inflammatory muscle diseases-polymyositis and dermatomyositis and related disorders-will examine what causes these diseases and describe the clinical features (signs and symptoms) associated with them. Inflammation and degeneration of skeletal muscles in these disorders leads to weakness and muscle wasting. The skin, lungs and other organs may also …

biopsy incision
x-rays
white blood cells
apheresis
urine tests
  • 844 views
  • 20 Sep, 2022
  • 1 location
Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile Dermatomyositis

Purpose The purpose of this protocol is 1. To comprehensively evaluate patients with autoinflammatory diseases clinically, genetically and immunologically at the autoinflammatory disease clinic at the NIH. 2. To follow patients with autoinflammatory Diseases that are genetically defined including Neonatal-Onset Multisystem Inflammatory Disease (NOMID), the most severe clinical phenotype of …

x-rays
skin inflammation
computerized tomography
dermatomyositis
skin disease
  • 537 views
  • 23 Sep, 2022
  • 1 location
Studies of Immunologically-Mediated Kidney Diseases

Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders

membranous nephropathy
glomerulonephritis
autoimmune diseases
nephritis
lupus
  • 230 views
  • 15 Sep, 2022
  • 1 location
Investigations of Bone-Related Connective Tissue Disorders

This study offers evaluation and treatment of patients with a suspected connective tissue disorder. The protocol is not designed to test new treatments; rather, patients receive standard care

connective tissue disorder
x-rays
rheumatism
blood drawing
Accepts healthy volunteers
  • 626 views
  • 18 Sep, 2022
  • 1 location
Natural History Study: Gene First Approach to Connective Tissue Disease

connective tissue disease. They may have a dental exam or eye exams and with photography. During the eye exam, pictures may be taken of the blood vessels in the eyes. If this occurs, they will get dye

stress test
  • 0 views
  • 15 Sep, 2022
  • 1 location
Study of the Natural History, Pathogenesis and Outcome of Melorheostosis - a Rare Osteosclerotic Disease

Background The rare disease melorheostosis causes bones to thicken. This may lead to pain, and can affect bones, joints, and muscles. Researchers want to learn more about the disease and how it progresses. Objective -To see what happens to people with melorheostosis over time and understand the causes of the …

x-rays
melorheostosis
probe
urine test
electrical shock
  • 15 views
  • 21 Sep, 2022
  • 1 location
The Research Registry for Neonatal Lupus

Women with lupus and other related disorders produce certain antibodies in the blood. Some women have these antibodies even if they have not yet developed symptoms of lupus or Sjogren's syndrome. When these women become pregnant, they may pass the antibodies to their infants. The infants may then develop a …

rash
sjogren's syndrome
lupus
Accepts healthy volunteers
  • 51 views
  • 19 Sep, 2022
  • 1 location