Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 88 clinical trials
Environmental Risk Factors for the Anti-synthetase Syndrome

Background Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors. Some researchers believe that people who are susceptible to autoimmune disorders develop them when the body reacts to environmental or other factors by creating white blood cells that attack the body s …

house dust
chest x-ray
white blood cells
pulmonary function test
myositis
  • 142 views
  • 12 Sep, 2021
  • 5 locations
The Personalised Antibiotic Duration for Cellulitis (PAD-C) Study

Cellulitis is an increasingly common and unpleasant bacterial infection of the skin, usually affecting the legs. Patients experience pain and swelling, loss of mobility, fever, and chills. Patients may be left with chronic skin damage and 1 in 5 experience recurrences. Cellulitis is treated with antibiotics, but it is unclear …

  • 0 views
  • 12 Sep, 2021
  • 1 location
Post-contracture Release Radiation for Dupuytren's Disease

To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.

dupuytren's contracture
  • 50 views
  • 10 Sep, 2021
  • 1 location
Clinical Genetic and Epidemiologic Study of Children and Adults With RASopathies

Background The RASopathies are a clinically defined group of disorders caused by germline mutations in genes encoding components of the Ras/mitogen-activated-protein kinase (Ras/MAPK) pathway. These disorders have overlapping clinical features due to Ras/MAPK dysfunction, including a predisposition to the development of certain malignancies. The aims of this prospective longitudinal cohort …

  • 0 views
  • 19 Sep, 2021
  • 1 location
Metabolomic Analysis of Systemic Sclerosis

occurs Diagnosis: to compare the metabolomics profile of SSc to undifferentiated connective tissue disease (UCDT), Raynaud's disease (RD), vascular disease (VD) and healthy controls

raynaud's syndrome
raynaud's phenomenon
systemic sclerosis
myocardial infarction
vascular disorder
  • 196 views
  • 11 Sep, 2021
  • 5 locations
New Orleans Pulmonary Hypertension Biobank

Pulmonary hypertension (PH) is a serious condition characterized by a mean pulmonary artery pressure >=25mmHg on right heart catheterization (RHC). Despite advances in PH care, outcomes are still sub-optimal and further research is required into the pathobiology of the disease and development of biomarkers that can guide clinical care. The …

right heart catheterization
systemic sclerosis
mixed connective tissue disease
progressive systemic sclerosis
hypertension
  • 102 views
  • 18 Sep, 2021
  • 1 location
The Pathogenesis and Natural History of Sjogren s Syndrome

Background -Sjogren s syndrome is a disease that affects about 1-4 million Americans. It is more common in women. It mainly affects the glands that produce saliva and tears, leading to dry eyes and dry mouth. The cause of Sjogren s syndrome is unknown, but inflammation plays an important role. …

vasculitis
fatigue
dry eyes
keratoconjunctivitis sicca
arthritis
  • 684 views
  • 19 Sep, 2021
  • 1 location
KD025 in Subjects With Diffuse Cutaneous Systemic Sclerosis

This randomized, placebo-controlled phase 2 study is seeking to evaluate the efficacy and safety of belumosudil (KD025) for the treatment of diffuse cutaneous systematic sclerosis. Upon eligibility confirmation, a total of 60 adult subjects will be enrolled and randomized into 3 groups (1:1:1) to either receive orally administered belumosudil (200 …

raynaud's syndrome
mycophenolate
raynaud's phenomenon
absolute neutrophil count
progressive systemic sclerosis
  • 201 views
  • 19 Sep, 2021
  • 35 locations
Open-label Extension Denosumab Study in Children and Young Adults With Osteogenesis Imperfecta

To evaluate long-term safety of denosumab in subjects with pediatric osteogenesis imperfecta (OI) who completed end of study (EOS) on Study 20130173.

  • 17 views
  • 19 Sep, 2021
  • 39 locations
Efficacy and Safety of Belumosudil in Subjects With Diffuse Cutaneous Systemic Sclerosis

This is a phase 2, open-label, single-cohort, multicenter trial of belumosudil in subjects with Diffuse Cutaneous Systemic Sclerosis (dcSSc). An estimated total of 12 to 15 subjects will receive belumosudil 200 mg administered orally (PO) twice daily (BID) for 52 weeks. The primary analysis will be at 24 weeks.

  • 0 views
  • 19 Sep, 2021
  • 6 locations