Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 42 clinical trials
A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) (ZENITH)

The objective of this study is to evaluate the effects of sotatercept (MK-7962, formerly called ACE-011) treatment (plus maximum tolerated background pulmonary arterial hypertension (PAH) therapy) versus placebo (plus maximum tolerated background PAH therapy) on time to first event of all cause death, lung transplantation, or PAH worsening-related hospitalization of …

  • 0 views
  • 10 Aug, 2022
  • 39 locations
BCMA-CD19 cCAR T Cell Treatment of Relapsed/Refractory Systemic Lupus Erythematosus (SLE)

This is a phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of BCMA-CD19 cCAR T cells in patients with relapsed and/or refractory SLE.

  • 0 views
  • 09 Aug, 2022
  • 1 location
Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)

The purpose of this study is to determine if Rozibafusp Alfa could be a useful therapeutic agent in the current treatment landscape where subjects with systemic lupus erythematosus (SLE) have ongoing disease activity despite treatment with standard of care therapies.

vasculitis
nephritis
antinuclear antibody
lupus
mouth ulcer
  • 101 views
  • 08 Aug, 2022
  • 127 locations
A DOSE-RANGING STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-06700841 IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Assessment of PF-06700841 in participants with moderate to severe active, generalized Systemic Lupus Erythematosus (SLE) that have inadequate response to standard of care.

azathioprine
leflunomide
lupus
antimalarials
mycophenolate
  • 233 views
  • 09 Aug, 2022
  • 126 locations
Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis

The purpose of this study is to evaluate the safety and effectiveness of treatment with branebrutinib treatment in participants with active systemic Lupus Erythematosus (SLE) or Primary Sjögren's Syndrome (pSS), or branebrutinib treatment followed by open-label abatacept treatment in study participants with active Rheumatoid Arthritis (RA).

progressive systemic sclerosis
arthritis
abatacept
lupus
sjogren's syndrome
  • 399 views
  • 11 Aug, 2022
  • 66 locations
Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus (Tulip SC)

The purpose of this study is evaluating the efficacy and safety of SC antifrolumab in adult patients with moderate -to-severe SLE despite receiving standard therapy

anifrolumab
lupus
  • 0 views
  • 09 Aug, 2022
  • 76 locations
The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW)

The purpose of this Proof of Concept (PoC) and Dose-finding (DF) basket study is to evaluate the efficacy and safety of orally administered M5049 over 24 weeks in systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE; subacute cutaneous lupus erythematosus [SCLE] and/or discoid lupus erythematosus [DLE]) participants in a …

cutaneous lupus
estrogen
corticosteroids
lupus
  • 0 views
  • 11 Aug, 2022
  • 31 locations
An Extension Study for Participants Who Have Completed the Treatment Period of a Qualifying Parent Study

The purpose of this research study is to evaluate the long-term safety, and tolerability of PF-06823859 study drug in adult participants with Dermatomyositis (DM) from a qualifying study.

dermatomyositis
  • 0 views
  • 10 Aug, 2022
  • 21 locations
Fibromyalgia Integrative Training for Adolescents With Juvenile Fibromyalgia (FIT Teens)

This study evaluates whether Fibromyalgia Integrative Training program for Teens (FIT Teens), a combined cognitive behavioral therapy and neuromuscular exercise training program is more effective in reducing disability in adolescents with Juvenile Fibromyalgia compared to cognitive behavioral therapy (CBT) alone or a graded aerobic exercise (GAE) program alone. One third …

behavioral therapy
fibromyalgia
aerobic exercise
cognitive therapy
  • 577 views
  • 10 Aug, 2022
  • 5 locations
COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases (COVBIRD)

People living with Systemic autoimmune rheumatic diseases (SARDs) face a new and urgent dilemma: immunosuppression increases risk for worse COVID-19 infection, yet an immune stimulation, such as vaccination, could re-activate their disease. Fear of vaccine-related disease reactivation is not of concern in other immunosuppressed groups (e.g. patients receiving chemotherapy or …

monoclonal antibodies
vasculitis
lupus
progressive systemic sclerosis
immunosuppression
  • 6 views
  • 08 Aug, 2022
  • 1 location