Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 272 clinical trials
Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma

Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma

soft tissue sarcoma
ipilimumab
  • 2 views
  • 25 Jan, 2021
  • 1 location
Talimogene Laherparepvec Nivolumab and Trabectedin for Sarcoma

This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.

metastatic sarcoma
advanced sarcoma
platelet count
trabectedin
kidney function tests
  • 1 views
  • 24 Jan, 2021
  • 1 location
Hypofractionated Radiotherapy for Soft Tissue Sarcomas

One of the main challenges in treating sarcomas with radiation is the toxicity to normal structures around the sarcoma. Early reports suggest Hypofractionated Radiotherapy will be safe and effective for treatment of soft tissue sarcomas. However, given the rarity of this disease, the diversity of histological sub-types, and the variety …

soft tissue sarcoma
  • 13 views
  • 20 Mar, 2021
  • 1 location
FAZA PET/MRI Sarcoma

This is a single arm, single centre, investigator initiated study to investigate the use of FAZA-PET in combination with MRI. FAZA is an investigational radiotracer used in PET scans. FAZA PET/MRI will be used to measure hypoxia in sarcoma tissues of 14 patients who plan to undergo neoadjuvant radiation/chemotherapy treatment. …

leiomyosarcoma
synovial sarcoma
undifferentiated pleomorphic sarcoma
liposarcoma
mpnst
  • 17 views
  • 18 Apr, 2021
  • 1 location
High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas

This is a single-arm open-label phase Ib/II clinical study assessing the efficacy of concurrent high dose ascorbate in combination with radiotherapy in patients with locally advanced, resectable, high grade sarcomas.

soft tissue sarcoma
cancer
carcinoma
measurable disease
ct scan
  • 3 views
  • 07 Jul, 2021
  • 1 location
A Study of Pazopanib and Durvalumab for Metastatic Soft Tissue Sarcoma

Pazopanib is an angiogenesis inhibitor targeting VEGFR-1, -2, and -3; PDGFR- and -; and the receptor c-Kit, and is indicated for the treatment of subjects with advanced renal cell carcinoma (RCC) and advanced STS. For this orphan tumor, STS, PD-L1 targeting may be a promising strategy and favorable toxicity may …

metastatic soft tissue sarcoma
soft tissue sarcoma
cancer
carcinoma
measurable disease
  • 1 views
  • 01 May, 2021
  • 1 location
A Single-arm Open Phase II Study of Chidamide Combined With Toripalimab in Refractory and Advanced Soft-tissue Sarcoma

Soft tissue sarcoma is a relatively rare malignant tumor with an incidence of about 1-2/100,000. The best way to obtain evidence-based medical evidence is to participate in clinical trials with new drugs (especially targeted drugs and immunotherapy). Chidamide, an oral subtype-selective histone deacetylase inhibitor monotherapy was effective on the patients …

soft tissue sarcoma
fibrosarcoma
neutrophil count
leiomyosarcoma
synovial sarcoma
  • 2 views
  • 24 Mar, 2021
  • 1 location
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum

The purpose of this study is to determine if treatment with the investigational drug 131I-Omburtamab can prevent or delay the worsening of Desmoplastic Small Round Cell Tumors/DSRCT or other cancers of the peritoneum.

desmoplastic
tumor progression
cancer chemotherapy
  • 24 views
  • 27 Jan, 2021
  • 2 locations
A Study of SHR-1210 Plus Apatinib in Patients With Soft Tissue Sarcoma

The main purpose of this study is to evaluate the efficacy of SHR-1210 plus Apatinib versus AMD plus IFO in participants with soft tissue sarcoma.

metastatic soft tissue sarcoma
soft tissue sarcoma
apatinib
kidney function tests
measurable disease
  • 2 views
  • 23 Jan, 2021
Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

The investigators are doing this study to find out whether lowering the dose of postoperative radiation therapy and targeting a smaller area of tissue for treatment is as effective as the standard dose and volume of radiation therapy to control soft tissue sarcoma after surgery. They also want to find …

soft tissue sarcoma
immunomodulators
sarcoma of the extremity
cancer chemotherapy
  • 0 views
  • 06 Jul, 2021
  • 7 locations