Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 217 clinical trials
Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma

The purpose of this study is to determine whether Lithium Carbonate combined with neo-adjuvant chemotherapy improve the prognosis of osteosarcoma

MRI
cancer chemotherapy
  • 13 views
  • 21 Jan, 2021
  • 1 location
A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma

This is a Phase 1+2, open-label, dose-escalation, and multidose study, aiming to investigate the safety, tolerability and pharmacokinetics of ZKAB001 (a fully human monoclonal antibody targeting the Programmed Death - Ligand 1 (PD-L1) membrane receptor on T lymphocytes and other cells of the immune system) administered every 14 days in …

monoclonal antibodies
renal function
immunomodulators
doxorubicin
neutrophil count
  • 7 views
  • 14 Feb, 2022
  • 1 location
Mifamurtide Combined With Post-operative Chemotherapy for Newly Diagnosed High Risk Osteosarcoma Patients (SARCOME13)

Trial evaluating the impact on efficacy of mifamurtide as add-on treatment to post-operative chemotherapy compared to post-operative chemotherapy alone in first-line treatment of patients with high-risk osteosarcoma (defined as metastatic osteosarcoma at diagnosis or localised osteosarcoma with poor histological response).

metastasis
metastatic osteosarcoma
ifosfamide
mifamurtide
etoposide
  • 12 views
  • 14 Feb, 2022
  • 6 locations
Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma

This early phase I trial studies how well glucarpidase works in reducing toxicity in patients with osteosarcoma receiving high dose methotrexate treatment. Glucarpidase may reduce the levels of methotrexate in patients' blood and lead to shorter hospitalizations and a reduction in toxicities.

neutrophil count
glomerular filtration rate
platelet count
methotrexate
doxorubicin
  • 14 views
  • 05 Jul, 2022
  • 5 locations
Losartan + Sunitinib in Treatment of Osteosarcoma

This study is a Phase 1/1b clinical trial that aims to determine the Maximally Tolerated Dose of Losartan and Sunitinib Combination Therapy. Patients will first be accrued to the Dose Escalation phase of the study, using a 3+3 design. Medication dosages will increase until a maximally tolerated dose is found. …

growth factor
cellular therapy
metastasis
renal function
myelosuppressive chemotherapy
  • 0 views
  • 28 May, 2022
  • 2 locations
Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy in the Treatment of Osteosarcoma

This study is a open-lable, , single center, phase II clinical study. Target population is patients with locally resectable osteosarcoma. Study objective is to compare the efficacy and safety of camrelizumab in combination with adriamycin, cisplatin, ifosfamide and methotrexate in study population in China. Camrelizumab is a humanized anti-PD1 IgG4 …

resectable osteosarcoma
adriamycin
ifosfamide
monoclonal antibodies
measurable disease
  • 0 views
  • 28 Feb, 2022
  • 1 location
18F-FTC-146 PET/CT in Newly-Diagnosed Osteosarcoma

The purpose of this research is to evaluate the study drug, 18F FTC-146, as a positron emission tomography (PET) / computed tomography (CT) radiotracer imaging agent to evaluate tumor status in patients newly diagnosed with osteosarcoma ("bone cancer").

cancer
bone cancer
cancer chemotherapy
  • 0 views
  • 29 Apr, 2022
  • 1 location
Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients (TRASTS)

Phase I-II trial that combines trabectedin plus radiotherapy for tumor reduction response measure in two cohorts of patients: Cohort A: Patients with diagnosis of non-operable or unresectable or not oncologically recommended metastasectomy of limited to lung metastases soft tissue sarcoma. Cohort B: Patients with locally advanced resectable Myxoid Liposarcoma. Cohort …

myxoid liposarcoma
angiosarcoma
undifferentiated pleomorphic sarcoma
mpnst
malignant peripheral nerve sheath tumor
  • 25 views
  • 17 Jun, 2022
  • 13 locations
Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma

Background Kaposi sarcoma (KS) is a cancer most often seen in people with HIV. It causes lesions. These are usually on the skin but sometimes in the lymph nodes, lungs, and gastrointestinal tract. Researchers think a combination of drugs may help treat KS. Objective To test a combination of the …

progressive disease
antiretroviral agents
diastolic blood pressure
antiretroviral therapy
systemic chemotherapy
  • 11 views
  • 25 Jul, 2022
  • 1 location
NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Background Kaposi sarcoma (KS) tumors grow on the skin, lymph nodes, lungs, bone, and gastrointestinal tract. KS often affects people with immune deficiencies, such as among people living with HIV or those with prior history of transplant. Researchers want to see if 2 non-chemotherapy drugs can help people with KS. …

progressive disease
monoclonal antibodies
atazanavir
AIDS
protease
  • 12 views
  • 22 Jul, 2022
  • 1 location