Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 268 clinical trials
Pemetrexed Cisplatin With Soft Tissue Sarcoma

Soft tissue sarcoma (STS) is rare malignancy of mesodermal origin, representing less than 1% of all malignant neoplasms. They are a group of diseases encompassing diverse histological subtypes with very different biomorphologies, prognoses, and responses to treatments. At advanced stages of STS, anticancer treatments are less effective and the prognosis …

  • 0 views
  • 02 May, 2021
  • 1 location
Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b Trial

The purpose of this single arm open label phase 1b clinical study is to see what effect zoledronic acid has on tumors in patients with resectable any grade chondrosarcoma prior to surgery.

platelet count
calcium
cancer chemotherapy
neutrophil count
  • 7 views
  • 26 Jan, 2021
  • 1 location
Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma

This early phase I trial studies how well glucarpidase works in reducing toxicity in patients with osteosarcoma receiving high dose methotrexate treatment. Glucarpidase may reduce the levels of methotrexate in patients' blood and lead to shorter hospitalizations and a reduction in toxicities.

methotrexate
doxorubicin
glomerular filtration rate
platelet count
neutrophil count
  • 8 views
  • 25 Jan, 2021
  • 4 locations
Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy in the Treatment of Osteosarcoma

This study is a open-lable, , single center, phase II clinical study. Target population is patients with locally resectable osteosarcoma. Study objective is to compare the efficacy and safety of camrelizumab in combination with adriamycin, cisplatin, ifosfamide and methotrexate in study population in China. Camrelizumab is a humanized anti-PD1 IgG4 …

methotrexate
ifosfamide
adriamycin
resectable osteosarcoma
cancer chemotherapy
  • 0 views
  • 23 Jan, 2021
  • 1 location
Clinical Trial Evaluating Metronomic Chemotherapy in Patients With Metastatic Osteosarcoma

Preclinical models show that a daily antiangiogenic regimen at low-dose may be effective against chemotherapy-resistant tumors. The aim of this study is to evaluate the efficacy of maintenance therapy with continuous oral cyclophosphamide and methotrexate in patients with high grade, operable, metastatic osteosarcoma (OST) of the extremities. The primary end …

cancer chemotherapy
metastatic osteosarcoma
methotrexate
cancer
  • 58 views
  • 21 Jan, 2021
  • 1 location
Mifamurtide Combined With Post-operative Chemotherapy for Newly Diagnosed High Risk Osteosarcoma Patients

Trial evaluating the impact on efficacy of mifamurtide as add-on treatment to post-operative chemotherapy compared to post-operative chemotherapy alone in first-line treatment of patients with high-risk osteosarcoma (defined as metastatic osteosarcoma at diagnosis or localised osteosarcoma with poor histological response).

methotrexate
schwartz
etoposide
cancer chemotherapy
doxorubicin
  • 4 views
  • 04 Apr, 2021
  • 31 locations
QUILT-3.031: AMG 337 in Subjects With Advanced or Metastatic Clear Cell Sarcoma

This is a phase 2 study that will assess the efficacy of AMG 337 in subjects with advanced or metastatic clear cell sarcoma that contains the EWSR1-ATF1 gene fusion.

ifosfamide
platelet count
kidney function tests
measurable disease
neutrophil count
  • 32 views
  • 25 Jan, 2021
  • 2 locations
Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE)

This research study is studying a drug as a possible treatment for Angiosarcoma or Epithelioid hemangioendothelioma (EHE). -The drug involved in this study is Eribulin

  • 2 views
  • 15 Feb, 2021
A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma

This is a Phase 1+2, open-label, dose-escalation, and multidose study, aiming to investigate the safety, tolerability and pharmacokinetics of ZKAB001 (a fully human monoclonal antibody targeting the Programmed Death - Ligand 1 (PD-L1) membrane receptor on T lymphocytes and other cells of the immune system) administered every 14 days in …

renal function
cancer chemotherapy
doxorubicin
platelet count
monoclonal antibodies
  • 7 views
  • 22 Jan, 2021
  • 1 location
A Study of sEphB4-HSA in Kaposi Sarcoma

sEphB-HSA may prevent tumor cells from multiplying and blocks several compounds that promote the growth of blood vessels that bring nutrients to the tumor. The purpose of this study is to learn if sEphB4-HSA will decrease the number or size of Kaposi sarcoma lesions in people.

KIT
doxorubicin
oophorectomy
tumor cells
HIV Infection
  • 0 views
  • 26 Jan, 2021
  • 3 locations