Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 271 clinical trials
A Study of PTC596 (Unesbulin) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

The primary objective of this study is to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of PTC596 in combination with dacarbazine for the treatment of advanced LMS and determine the overall safety profile of PTC596 in combination with dacarbazine. This study will employ the time-to-event …

platelet count
cancer
hormone therapy
carcinoma
metastasis
  • 6 views
  • 13 Jun, 2021
  • 3 locations
A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

The purpose of this study is to find out whether combining the study drugs rucaparib and nivolumab may be an effective treatment for advanced and/or metastatic LMS, and whether the study treatment works as well as the standard chemotherapy for this type of cancer.

cancer
cancer chemotherapy
systemic therapy
EGFR
neutrophil count
  • 0 views
  • 28 Jun, 2021
  • 7 locations
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas

The main objective of this project is to identify a new non-invasive biological test for the diagnosis of LPS by measuring circulating serine levels. The current gold standard is the detection of Mdm2 amplification by the FISH.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma

Phase I-II, randomized, open-label, multicenter, international clinical trial Patients with advanced soft-tissue sarcoma (undifferentiated pleomorphic sarcoma, leiomyosarcoma, alveolar soft-part sarcoma) and osteosarcoma will receive selinexor in combination with gemcitabine.

undifferentiated pleomorphic sarcoma
platelet count
gemcitabine
systemic therapy
anthracyclines
  • 0 views
  • 16 Jul, 2021
  • 6 locations
Anlotinib Combined With Toripalimab in Refractory and Advanced Soft-tissue Sarcoma

Soft tissue sarcoma (STS) is a relatively rare type of malignant tumor with an incidence of 1-2/100000. For unresectable or widely disseminated advanced STS, a combined clinical trial is the best way to obtain evidence-based medical evidence. Anlotinib, a multi-target receptor tyrosine kinase inhibitor (TKI), is effective for various histological …

undifferentiated pleomorphic sarcoma
fibrosarcoma
epithelioid sarcoma
malignant peripheral nerve sheath tumor
metastasis
  • 0 views
  • 26 Jan, 2021
  • 1 location
Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion

The study is a randomized, open, prospective phase II study. The aim of the study is to evaluate the safety and feasibility of a hypofractionated, accelerated radiation approach based on the incidence of grade 3-5 NCI Common Terminology Criteria for Adverse Events (NCI-CTC-AE ) toxicity and / or termination of …

soft tissue sarcoma
  • 1 views
  • 01 Jul, 2021
  • 1 location
The Combination of Sintilimab and AI (Doxorubicin ADM/Ifosfamide IFO) for the First Line Treatment of Select Type of Metastatic/Unresectable Soft Tissue Sarcoma

This is a phase II trial to explore the feasibility of PD-1 immune check point inhibitor, sintilimab, in combination of stand of care chemotherapy in first-line treatment of selected soft tissue sarcoma.

undifferentiated pleomorphic sarcoma
cancer chemotherapy
myxoid liposarcoma
metastasis
synovial sarcoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma

The proposed study is a two-step trial with 1) a safety run in part conducted in pediatric patients and 2) a Phase II part in adult and pediatric patients aiming to evaluate the safety and clinical activity of atezolizumab + cobimetinib in advanced/metastatic soft tissue sarcomas.

cancer
cancer chemotherapy
epithelioid sarcoma
myxoid liposarcoma
immunomodulators
  • 5 views
  • 19 Feb, 2021
  • 8 locations
Pemetrexed Cisplatin With Soft Tissue Sarcoma

Soft tissue sarcoma (STS) is rare malignancy of mesodermal origin, representing less than 1% of all malignant neoplasms. They are a group of diseases encompassing diverse histological subtypes with very different biomorphologies, prognoses, and responses to treatments. At advanced stages of STS, anticancer treatments are less effective and the prognosis …

  • 0 views
  • 02 May, 2021
  • 1 location
Clinical and Biological Activity of an Anti-PD-L1 (Atezolizumab) in Operable Localised Soft Tissue Sarcomas Patients to be Treated With Radiotherapy

This multicentric, randomised, Phase II trial will use a pick-the-winner design in order to evaluate the clinical and biological activity of atezolizumab when combined with pre-operative or post-operative radiotherapy in STS patients. Following Inform Consent Form (ICF) signature, eligible patients will be randomised (1:1:1) to receive: Arm A: Radiotherapy followed …

  • 8 views
  • 13 May, 2021
  • 6 locations