Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 217 clinical trials
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

corticotropin
solid tumors
solid tumour
metastases
germ cell tumor
  • 6634 views
  • 10 Aug, 2022
  • 752 locations
MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma (COTESARC)

The proposed study is a two-step trial with 1) a safety run in part conducted in pediatric patients and 2) a Phase II part in adult and pediatric patients aiming to evaluate the safety and clinical activity of atezolizumab + cobimetinib in advanced/metastatic soft tissue sarcomas.

alveolar soft part sarcoma
angiosarcoma
metastatic soft tissue sarcoma
epithelioid sarcoma
cancer
  • 5 views
  • 23 Apr, 2022
  • 4 locations
The Combination of Sintilimab and AI (Doxorubicin ADM/Ifosfamide IFO) for the First Line Treatment of Select Type of Metastatic/Unresectable Soft Tissue Sarcoma

This is a phase II trial to explore the feasibility of PD-1 immune check point inhibitor, sintilimab, in combination of stand of care chemotherapy in first-line treatment of selected soft tissue sarcoma.

metastasis
solid tumour
ifosfamide
synovial sarcoma
myxoid liposarcoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
Clinical and Biological Activity of an Anti-PD-L1 (Atezolizumab) in Operable Localised Soft Tissue Sarcomas Patients to be Treated With Radiotherapy (RT-Immune)

This multicentric, randomised, Phase II trial will use a pick-the-winner design in order to evaluate the clinical and biological activity of atezolizumab when combined with pre-operative or post-operative radiotherapy in STS patients. Following Inform Consent Form (ICF) signature, eligible patients will be randomised (1:1:1) to receive: Arm A: Radiotherapy followed …

angiosarcoma
leiomyosarcoma
cancer
myxoid liposarcoma
liposarcoma
  • 30 views
  • 24 Apr, 2022
  • 5 locations
Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma

Phase I-II, randomized, open-label, multicenter, international clinical trial Patients with advanced soft-tissue sarcoma (undifferentiated pleomorphic sarcoma, leiomyosarcoma, alveolar soft-part sarcoma) and osteosarcoma will receive selinexor in combination with gemcitabine.

alveolar soft part sarcoma
leiomyosarcoma
systemic therapy
undifferentiated pleomorphic sarcoma
platelet count
  • 0 views
  • 25 Nov, 2021
  • 7 locations
Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion

The study is a randomized, open, prospective phase II study. The aim of the study is to evaluate the safety and feasibility of a hypofractionated, accelerated radiation approach based on the incidence of grade 3-5 NCI Common Terminology Criteria for Adverse Events (NCI-CTC-AE ) toxicity and / or termination of …

soft tissue sarcoma
  • 1 views
  • 01 Jul, 2021
  • 1 location
A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

The primary objective of this study is to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of unesbulin in combination with dacarbazine for the treatment of advanced LMS and determine the overall safety profile of unesbulin in combination with dacarbazine. This study will employ the time-to-event …

metastasis
dacarbazine
hormone therapy
leiomyosarcoma
cancer
  • 14 views
  • 09 Jul, 2022
  • 4 locations
A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

The purpose of this study is to find out whether combining the study drugs rucaparib and nivolumab may be an effective treatment for advanced and/or metastatic LMS, and whether the study treatment works as well as the standard chemotherapy for this type of cancer.

leiomyosarcoma
cancer
EGFR
systemic therapy
immunomodulators
  • 0 views
  • 29 Sep, 2021
  • 7 locations
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas

The main objective of this project is to identify a new non-invasive biological test for the diagnosis of LPS by measuring circulating serine levels. The current gold standard is the detection of Mdm2 amplification by the FISH.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction

This study intends to determine if any correlation exists between administration of TXA or not to musculoskeletal oncology patients undergoing endoprosthetic reconstruction and blood loss and blood transfusion rates.

soft tissue sarcoma
  • 0 views
  • 04 Jun, 2022
  • 1 location