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Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (159) clinical trials

Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With BL/DLBCL

Research purposes: To investigate the efficacy and safety of SCCCG-BL/DLBCL-2017 in children with BL and DLBCL. To investigate the effect of rituximab combined with chemotherapy on the survival rate of children with high-risk BL/DLBCL. To investigate the effect of rituximab on immune function in children with high-risk BL/DLBCL. To explore ...

Phase N/A

A Study of Oral LOXO-292 in Pediatric Patients With Advanced Solid or Primary Central Nervous System Tumors

This study includes 2 parts: phase 1 (dose escalation) and phase 2 (dose expansion). In phase 1, patients will be enrolled using a rolling 6 dose escalation scheme. The starting dose of LOXO-292 is equivalent to the adult recommended phase 2 dose of 160mg BID. Once the MTD and/or RP2D ...

Phase

Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

PRIMARY OBJECTIVES To evaluate the efficacy (adequate response) after 2 cycles of BEABOVP (bendamustine substitution for mechlorethamine in the original Stanford V chemotherapy backbone) in low-risk and intermediate-risk patients with classical Hodgkin lymphoma (cHL). To estimate the event-free survival in high-risk patients with classical Hodgkin lymphoma (cHL). SECONDARY OBJECTIVES To ...

Phase

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Research purpose: To investigate the efficacy and safety of SCCCG-LBL-2017 in Chinese children with LBL. To explore the feasibility of risk stratification of T-LBL by combining genotyping. To investigate the correlation between MDD and MRD in lymphoblastic lymphoma and prognosis. To investigate the role of PET/CT in the assessment of ...

Phase N/A

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With Systemic ALK(+) ALCL

Research purpose: To study the efficacy and safety of SCCCG-ALCL-2017 regimen in children with systemic ALK-positive anaplastic large cell lymphoma. To explore the correlation between MDD or MRD in peripheral blood or bone marrow and the treat response and survival. To explore the feasibility of risk stratification combined with adverse ...

Phase N/A

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

This study will evaluate palbociclib in combination with chemotherapy (temozolomide and irinotecan) in children, adolescents and young adults with recurrent or refractory solid tumors. The main purpose of this study is to evaluate the safety of palbociclib in combination with chemotherapy in order to estimate the maximum tolerated dose. Pharmacokinetics ...

Phase

Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation

This is a multicenter, interventional and observational study to understand factors affecting the likelihood of transplantation in patients without a human leukocyte antigen (HLA) matched family donor and to compare outcomes associated with pursuing an HLA-identical unrelated versus other alternative donor graft sources. Alternative donors are defined as any donor ...

Phase N/A

Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma Rhabdomyosarcoma Ewings Sarcoma and Osteosarcoma

Even with standard, highly toxic multimodality therapies and salvage regimen, most pediatric patients with primary metastatic or relapsed solid tumors are confronted with a poor prognosis. For these patients there is currently no accepted successful treatment regimen. There is a need for new drugs, including targeted radiopharmaceuticals, preferably with cancer-specific ...

Phase

Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitor BMS-986158 in Pediatric Cancer

This is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug to use for further studies. "Investigational" means that the drug is being studied. The FDA (the U.S. Food and Drug Administration) has not ...

Phase