Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 261 clinical trials
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COG D9902: Collecting and Storing Tissue, Blood, and Bone Marrow Samples from Patients with Rhabdomyosarcoma or Other Soft Tissue Sarcoma

COG D9902: Collecting and Storing Tissue, Blood, and Bone Marrow Samples from Patients with Rhabdomyosarcoma or Other Soft Tissue Sarcoma

  • 168 views
  • 08 Nov, 2020
  • 1 location
Surgery With Our Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to …

cancer
leiomyosarcoma
tubal occlusion
neutrophil count
gilbert's syndrome
  • 0 views
  • 18 Mar, 2021
  • 6 locations
A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma

This Is a Multicenter, Randomized, Open-Label, Parallel-Group, Phase 2 Study to Compare the Efficacy and Safety of Lenvatinib in Combination with Ifosfamide and Etoposide Versus Ifosfamide and Etoposide in Children, Adolescents, and Young Adults with Relapsed or Refractory Osteosarcoma.

etoposide
cancer
refractory osteosarcoma
ototoxicity
ifosfamide
  • 50 views
  • 19 Jun, 2021
  • 74 locations
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor

This study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory desmoplastic small round cell tumor (DSRCT) in children and young adults. This trial is part of the CAMPFIRE master protocol which is a platform …

kidney function tests
cancer
neutrophil count
filgrastim
immunomodulators
  • 3 views
  • 19 Jun, 2021
  • 70 locations
Molecular Profiling of Advanced Soft-tissue Sarcomas

MULTISARC is a randomized multicenter study assessing whether high throughput molecular analysis (next generation sequencing exome - NGS) is feasible in advanced/metastatic soft-tissue sarcoma patients, that is, whether NGS can be conducted for a large proportion of patients, with results available within reasonnable delays. In parallel, MULTISARC aims to assess …

KIT
EGFR
measurable disease
cancer
carcinoma
  • 15 views
  • 28 Jan, 2021
  • 23 locations
Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 Mutations

This is an open-label, multicenter Phase 1 study to evaluate safety, tolerability and preliminary efficacy of oral LY3410738 in patients with IDH1 R132-mutant advanced solid tumor types, including but not limited to cholangiocarcinoma, chondrosarcoma, and glioma.

immunomodulators
gemcitabine
measurable disease
systemic therapy
metastasis
  • 0 views
  • 18 Jun, 2021
  • 48 locations
Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Grade 1 or 2 Soft Tissue Sarcoma

Phase III, multicenter, randomized open-label and comparative study designed to demonstrate whether adding 4 cycles of peri-operative doxorubicin-based chemotherapy improves metastasis-free survival as compared with standard management in patients with resectable FNCLCC grade 1/2 STS, considered as high-risk according to CINSARC (Complexity Index in SARComas) signature. After signed informed consent, …

kidney function tests
metastasis
leiomyosarcoma
soft tissue sarcoma
dacarbazine
  • 0 views
  • 28 May, 2021
  • 22 locations
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging …

carboplatin
core needle biopsy
breast cancer
HER2
doxorubicin
  • 79 views
  • 07 May, 2021
  • 30 locations
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor.

kidney function tests
measurable disease
renal function
metastasis
RET
  • 22 views
  • 13 May, 2021
  • 31 locations
Development of Clinical and Biological Database

The BCB is a tool: for research in analytical and public health epidemiology, biological research and for the development of data useful for clinical research and therapeutic trials; to help scientists understand and explain phenomena ranging from the interaction of molecules to the whole metabolism of the organism in normal …

breast cancer
cancer
gastrointestinal cancer
sarcoma
anal canal
  • 4 views
  • 29 Apr, 2021
  • 1 location