Cerebral Palsy Clinical Trials

The CHAMP Study—a multisite clinical trial funded by the National Institutes of Health—compares the efficacy of alternative therapies for young children with unilateral spastic cerebral palsy, also known as hemiparetic cerebral palsy. Children who meet study eligibility criteria will participate at one of the three clinical sites— Roanoke, Virginia; Charlottesville, ...

The Baby Champ Study, a clinical trial funded by the National Institutes of Health, compares three highly promising forms of therapy for infants and toddlers who have a diagnosis of hemiparetic cerebral palsy. Children who meet study eligibility criteria will participate at one of the two clinical sites: Roanoke, Virginia, ...

The pupilometer determines the alteration of the pupil diameter after a defined light stimulus providing information of the autonomic nerve system. The result collecting from pupillometry is objective and more precise than the subjective-visual evaluation of the pupil and its reactivity. In this observational study data is collected from pupilometer ...

In 2013, a systematic review of interventions for children with cerebral palsy (Novak et al, 2013) concluded that constraint-induced movement therapy (CIMT) produces the largest magnitude effects of any non-surgical treatment. Similarly, the first major handbook summarizing the results from more than 50 studies on CIMT conducted worldwide (Ramey, Coker-Bolt, ...

Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary progressive aphasia (PPA), corticobasal degeneration syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). The goal of this study is to build a FTLD ...

What is the CHAMP Study? The CHAMP Study is a multisite clinical trial funded by the National Institutes of Health that is comparing the efficacy of alternative therapies for young children with unilateral spastic cerebral palsy (or hemiparetic cerebral palsy). Children who meet study eligibility criteria at one of the ...

There is an inverse relationship between birth weight or gestational age and risk for developmental impairment, with increasing incidence as birth weight or gestational age decreases. Serious impairment, defined as problems in body function or structure which may be temporary or permanent, is generally a more stable condition and typically ...

Coordinating health care professionals (HCPs; e.g. paediatric neurologists, physiotherapists) in different centres across different countries will be asked to participate in this cross-sectional study. for the HCP to fill out a questionnaire about their CP child, related to general subject characteristics, motor function, co-morbidities, type of therapies, anthropometry, feeding mode ...

Bracing severe neuromuscular scoliotic curves rarely serves as definitive treatment, thus most progressive curves require surgical intervention in order to sustain or improve sitting (or ambulatory) abilities. Surgery is a demanding intervention for these patients, with variable functional gains. Controversy persists regarding indications for surgery, timing, and technique. Concerns about ...

This study is a phase I/II, prospective, randomized, open-label trial designed to determine the effect size of change in GMFM-66 score in subjects treated with hCT-MSC or allogeneic CB and assess the safety of repeated doses of hCT-MSC in children with cerebral palsy. Children ages 2-5 years with cerebral palsy ...