Rectal Disorders Clinical Trials

A listing of Rectal Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 618 clinical trials
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases (CAIRO5)

Colorectal cancer patients with initially unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy. However, the optimal neoadjuvant induction regimen has not been defined, and no consensus exist on criteria for resectability. In this study colorectal cancer patients with initially unresectable liver-only metastases, as prospectively …

panitumumab
neutrophil count
bevacizumab
primary tumor
systemic therapy
  • 249 views
  • 07 Apr, 2022
  • 50 locations
Back-to-back Endoscopy Versus Single-pass Endoscopy and Chromoendoscopy in IBD Surveillance (HELIOS)

The current international guidelines for CRC surveillance in IBD recommend as first choice the use of chromoendoscopy, and as an alternative high-definition white light endoscopy (HDWLE) for optimal dysplasia detection, based on data from clinical trials. However, data on the superiority of CE over HDWLE are not consistent in literature. …

endoscopy
enteropathy
primary sclerosing cholangitis
  • 2 views
  • 06 Apr, 2023
  • 4 locations
Care for Colon 2015

The investigatior believe that implementing camera capsule endoscopy as a filter test to colonoscopy will increase screening participation, increase the number of individuals with detected intermediate- high risk adenomas or cancer, reduce the colonoscopy demand and reduce the number of complications.

  • 0 views
  • 27 Sep, 2021
  • 1 location
Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical Cancer (EMBRACEII)

adverse reaction rates for all affected organs (rectum, sigmoid, urinary bladder, and vagina) to increase the quality of life of patients with cervical carcinomas.

pet/ct scan
locally advanced cervical carcinoma
adenocarcinoma
mri of pelvis
squamous cell carcinoma
  • 4 views
  • 12 Feb, 2022
  • 1 location
A Phase 3, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Darvadstrocel in the Treatment of Complex Perianal Fistula in Pediatric Subjects With Crohn's Disease Over a Period of 24 Weeks and an Extended Follow-up Period for a Total of up to 52 Weeks

A perianal fistula is an abnormal passageway that develops between the rectum and the skin near the anus. The fistula is considered complex if it branches into several openings or an abscess is

ulceration
corticosteroids
mercaptopurine
luminal
monoclonal antibodies
  • 0 views
  • 21 Oct, 2022
  • 22 locations
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors (innovaTV 207)

This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are four parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In …

adenocarcinoma
gemcitabine
solid tumour
measurable disease
irinotecan
  • 247 views
  • 07 Oct, 2022
  • 33 locations
A Phase Ia/Ib Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-6036 as a Single Agent and in Combination With Other Anti-cancer Therapies in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.

bevacizumab
cetuximab
KRAS
ki-ras
erlotinib
  • 92 views
  • 27 Oct, 2022
  • 59 locations
Multicentric Phase II-III Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma After a Favorable Response to Induction Chemotherapy (GRECCAR14)

Locally advanced rectal carcinoma raise the issue of both the oncological control, local and general, and the therapeutic morbidity. Surgery alone can cure only one out of two patients, radiochemotherapy improves the local control but the metastatic risk remains about 30% with enhanced postoperative morbidity and poor functional results. The …

irinotecan
capecitabine
proctectomy
oxaliplatin
total mesorectal excision
  • 0 views
  • 23 Oct, 2022
  • 14 locations
Aspirin in Colorectal Cancer Liver Metastases (ASAC)

The ASAC trial is a Scandinavian, multi-center, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose acetylsalicylic acid (ASA) can improve disease free survival in patients treated with resection for colorectal cancer liver metastases (CRCLM). Several studies have shown beneficial effect of ASA on primary prevention of CRC …

primary tumor
cancer
liver metastasis
aspirin
metastasis
  • 205 views
  • 29 Apr, 2022
  • 15 locations
Clinical Database of Colorectal Robotic Surgery (ROBOT CR)

Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.

ulceration
ulcerative colitis
low anterior resection
colitis
cancer
  • 1 views
  • 12 Feb, 2022
  • 4 locations