Depression (Treatment-Resistant) Clinical Trials

A listing of Depression (Treatment-Resistant) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 77 clinical trials
Featured trial
Depression - Treatment Resistant

Still feeling symptoms of Depression after having taken a prescription Antidepressant?  If so, participating in our medical research study of an investigational drug may be an option for you.

antidepressants
depressed mood
depressive episode
depressive symptoms
  • 911 views
  • 16 Dec, 2022
  • 1 location
Featured trial
Depression

Depression...It interferes with the ability to work, eat, sleep and enjoy life.  If you are experiencing symptoms of depression, a clinical research study may be your next step.  

depressed mood
depressive symptoms
  • 703 views
  • 16 Dec, 2022
  • 1 location
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

depressive episode
depressive symptoms
depressive disorder
  • 2834 views
  • 07 Oct, 2022
  • 65 locations
Tianeptine for Treatment Resistant Depression

The study will be conducted in parallel at two sites: the Clinic for Aging, Anxiety and Mood Disorders (CAAM) at Columbia University/New York State Psychiatric Institute (CU/NYSPI) and the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM). The following procedures will be approved …

depressive disorder
snri
antidepressants
bupropion
mirtazapine
  • 41 views
  • 04 Oct, 2022
Prefrontal Cortical Stimulation (PCS) for Severe Treatment Resistant Depression

This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms. Participants receive intermittent electrical stimulation to the brain, which involves surgically placing electric leads in between the tough fibrous membrane covering the surface of the …

  • 0 views
  • 15 Oct, 2022
  • 1 location
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment Resistant Depression (ENLIGHTEN)

This study will be conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 2b study. Approximately 180 subjects with treatment resistant depression who meet all

  • 0 views
  • 21 Oct, 2022
  • 9 locations
Precision Targeting of Propofol-induced Electroencephalographic Slow Waves: a Novel Phase I/2 Paradigm for Treatment-resistant Major Depressive Disorder

Our overall hypothesis is that sleep slow-wave potentiation by propofol is a therapeutic pathway for enhancing slow wave sleep and alleviating treatment-resistant depression (TRD).

  • 0 views
  • 14 Oct, 2022
  • 1 location
A Phase 2a, Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression

The main purpose of this study is to assess the efficacy and safety of daily and intermittent dosing of MK-1942 compared to placebo among participants with Treatment-Resistant Depression (TRD

  • 76 views
  • 21 Oct, 2022
  • 31 locations
Repeated Ketamine Infusions for Treatment-Resistant Bipolar Disorder: A Randomized, Double-blind, Midazolam-controlled, Phase II Clinical Trial (KET-BD)

Growing evidence has supported rapid and robust antidepressant effects with subanesthetic doses of intravenous (IV) ketamine for treatment resistant depression (TRD). However, no completed or

  • 0 views
  • 19 Oct, 2022
  • 1 location
PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents (P2P)

PATH (Promoting AdolescenT Health) 2 Purpose is a two-arm comparative effectiveness research trial to that will evaluate the ability of the interventions, Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT) and Teens Achieving Mastery over Stress (TEAMS), to intervene early to prevent depressive illness and potentially other common mental …

depressed mood
behavior therapy
depressive disorder
Accepts healthy volunteers
depressive symptoms
  • 47 views
  • 04 Oct, 2022
  • 1 location