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Blood Transfusions Clinical Trials

A listing of Blood Transfusions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (80) clinical trials

The purpose of this study is to determine at what blood count patients should be given a transfusion. During this trial we will be assessing red blood cell transfusion strategies that are currently used in clinical practice and important medical events. Red blood cells are a limited and expensive medical ...

Phase

Australian and New Zealand Massive Transfusion Registry

Severe and unstopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies. The investigators understanding of how to best treat people with serious bleeding is still incomplete, with many questions remaining. These include ...

Phase N/A

Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion

Tranexamic Acid (TXA) is an antifibrolytic medication used in total hip and knee arthroplasty to reduce the need for intraoperative and postoperative blood transfusions. Limited research is available on its use in hip fracture patients. We hypothesize that the use of TXA preoperatively, perioperatively, and postoperatively will decrease blood loss ...

Phase

Platelet Transfusion Requirements in Hematopoietic Transplantation

In Canada, over 1,500 autologous hematopoietic stem cell transplantations (ASCT) are performed annually for hematologic malignancies. It is currently standard practice to provide a prophylactic transfusion of platelets to prevent bleeding when the daily measured platelet count is less than 10 x 109/L. A patient may require up to six ...

Phase

Deferasirox in Treating Patients With Very Low Low or Intermediate-Risk Red Blood Cell Transfusion Dependent Anemia or Myelodysplastic Syndrome

PRIMARY OBJECTIVES: I. To assess the activity of iron chelation therapy (ICT) with deferasirox, in patients with anemia as a result of myelodysplastic syndrome (MDS). SECONDARY OBJECTIVES: I. Reduction in red blood cell (RBC) transfusion requirements. II. Hematologic improvement. III. Change in serum ferritin levels from baseline to the end ...

Phase

Red Blood Cell Transfusion Thresholds and QOL in MDS

Myelodysplastic syndromes (MDS) are bone marrow malignancies characterized by poor bone marrow function that may progress to acute myeloid leukemia. Many patients become red blood cell transfusion-dependent. Transfusion dependence is associated with inferior quality of life (QOL). However, the relationship between the degree of anemia and QOL is less clear. ...

Phase N/A

Transfusion of Plasma Prior to Invasive Procedures Pilot Trial (TOPPIT)

There are 3 accepted indications for transfusing FP: bleeding in patients with prolonged coagulation tests that cannot be corrected with other products or medications, prior to surgery or invasive procedures in patients who have prolonged coagulation test that cannot be corrected with other products or medications and plasmapheresis for Thrombotic ...

Phase

Transfusion of Red Blood Cells for Acute Respiratory Distress Syndrome(ARDS) in Neonates

Acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. There are few options for mechanical ventilation for such situations such as high frequency oscillation ventilation and extracorporeal membrane oxygenation. The aim of the present ...

Phase N/A

R-FACT Study:Risk Factors for Alloimmunization After Red Blood Cell Transfusions

Introduction: Individuals exposed to red blood cell (RBC) alloantigens through transfusion, pregnancy, or transplantation may produce antibodies against the alloantigens expressed by RBCs. Although the incidence of these events is debated and ranges between percentages of 1-6% in single transfused patients and up to 30 % in poly-transfused patients (e.g. ...

Phase N/A

Caspofungin Based Combined Anti-fungal Therapy for Proven or Probable Invasive Fungal Infection

Patients will recieve caspofungin with either voriconazole or amphotericin B as combination therapy for fungal infection

Phase