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Chronic Pain Clinical Trials

A listing of Chronic Pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (387) clinical trials

Mechanistic Study of Duloxetine Versus Placebo in Breast Cancer Patients With Chronic Pain

Early stage breast cancer is typically treated with surgery, chemotherapy, radiation therapy, and/or endocrine therapy. Following treatment, 25-60% of breast cancer survivors have reported chronic pain, which can be difficult to manage. Duloxetine is a serotonin norepinephrine reuptake inhibitor that is FDA approved for treatment of depression, anxiety, fibromyalgia, diabetic ...


Neuroimaging Approaches to Deconstructing Acupuncture for Chronic Pain

This study design has two components: 1) a cross sectional assessment of brain chemistry, connectivity and response to pain in healthy controls and age- and sex-matched fibromyalgia patients, and 2) a longitudinal assessment of the same outcomes in fibromyalgia patients randomized to either electro-acupuncture or laser acupuncture. The investigators will ...

Phase N/A

Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance

This aim proposes that guanfacine would be a useful drug to deter Opioid-Induced Hyperalgesia (OIH) when combined with an opioid (morphine) in chronic pain management.


Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD

This study will explicitly compare the effects of a 12-week progressive exercise training program on 1) the clinical symptoms of chronic pain and PTSD, 2) pain threshold and tolerance, and 3) anti-stress, anti-nociceptive neurohormones such as neuropeptide Y (NPY) and allopregnanolone/pregnanolone (ALLO) in Veterans with chronic pain/PTSD compared to healthy ...

Phase N/A

Impact of the Ultrasound-guided Approach on the Efficiency and Safety of the Stellate Ganglion Block in Chronic Pain

To evaluate whether the ultrasound guided approach is more effective than the blind technique in producing a greater than 1.5 degree Celsius rise in ipsilateral arm temperature after a stellate ganglion block. Blocks will both be performed with 10 mL of xylocaine/bupivacaine. Secondary outcomes will be the impact of the ...

Phase N/A

HRV Biofeedback in Pain Patients

This study fulfills the national Veterans Health Administration/Department of Defense (VHA/DoD) Task Force recommendation that complementary, integrative therapies for pain management be provided to Veterans. Chronic pain elicits stress which increases sympathetic output fostering autonomic nervous system imbalance, an overextended stress response, fatigue, depression and insomnia. Heart Rate Variability (HRV) ...

Phase N/A

TEP Versus Open Repair of Sportsman's Hernia

Sportsman's hernia is defined as a weakness or disruption of the posterior wall of the inguinal canal. Open hernia repair with or without mesh or laparoscopic techniques with mesh have been advocated in the treatment of sportsman's hernia and associated athletic pubalgia. The results of the operative treatment from single ...

Phase N/A


The purpose of this study is to confirm the analgesic effect of tDCS in neuropathic chronic pain, to estimate the importance and the duration of this effect, and to improve its efficiency by the use at home. It is established that the repetition of the sessions of cortical stimulation over ...

Phase N/A

Autologous Tolerogenic Dendritic Cells for Treatment of Patients With Rheumatoid Arthritis

A phase I dose-escalating clinical trial will be conducted to determine the safety and tolerability of a single intra-articular injection (into the knee joint) of autologous tolerogenic dendritic cells, and to enable selection of a suitable dose regimen for phase II trial. The primary objective of the phase I study ...


PNE Effectiveness Cluster Trial

Chronic spinal pain is a very common and costly condition. An estimated 26.4% of Americans have experienced an episode low back pain (LBP) and 13.8% have experienced neck pain in the past 3 months. Lifetime prevalence of spinal pain ranges from 54% to 80% and the estimated healthcare costs for ...

Phase N/A