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Chronic Pain Clinical Trials

A listing of Chronic Pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (19) clinical trials

Nasal Fentanyl for Chronic Cancer Pain

Today, patients with cancer pain in need of opioids for moderate to severe pain get long-acting morphine twice a day and morphine tablets taken on demand in addition. This procedure might be based on the assumption that cancer pain is persistent, although the evidence to support whether this assumption applies ...

Phase

Intravenous Lidocaine in Carcinologic ENT Surgery: A Trial for Evaluation of Opioid Saving Strategy and Chronic Post-surgical Pain (ELICO)

Lidocaine, local anesthetic used for more than five decades, is being intravenously administered aiming at managing pain in different types of surgeries with promising results. Opioid-induced hyperalgesia need to be considered in ear-nose-throat (ENT) surgery owing to the difficulty of locoregional anesthesia and high level of opioid consumption. This randomized ...

Phase

Ketamine's Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway

The kynurenine pathway is involved in hyperalgesia. This pathway is activated by inflammation. Ketamine would interact with the kynurenine pathway and inflammation. Our working hypotheses are: the clinical effects of ketamine on neuropathic pain are greater in the presence of systemic inflammation and the mechanism of action involves an interaction ...

Phase

Efficacy of Fecal Microbiota Transplantation for Inflammatory Bowel Disease

Intestinal microbiota have a major role in disease pathogenesis, either in a form of a "permissive" role or as a direct pathogenic cause. Clostridium difficile colitis; irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have all been connected to a disturbance in the equilibrium of intestinal microbiome. The cause ...

Phase

Open-Label Safety and PK Study of ER Hydromorphone Tablets in Opioid-Tolerant Pediatric Chronic Pain Patients

This pediatric study is designed to provide safety information, dosing guidelines, and a pharmacokinetic (PK) evaluation of once-daily hydromorphone hydrochloride (HCl) extended-release (ER) tablets in children with chronic painful conditions who are "opioid-tolerant" prior to enrollment under the Pediatric Research Equity Act (PREA) of 2003.

Phase

Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms

Patients eligible for enrollment include: - Age 18-65 years - Symptomatic IC for at least six months - Urinary frequency of at least eleven voids in a 24 hour period - A self-rated global discomfort score of 4 or greater on a 0-10 scale Patients may not be enrolled who ...

Phase

Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1 Plexiform Neurofibromas and Chronic Pain

BACKGROUND Neurofibromatosis type 1 (NF1) is a genetic disorder that affects approximately 1 in 3,500 individuals. A number of common clinical manifestations, including plexiform neurofibromas, can cause frequent and significant pain and impact quality of life. Often, NF1-related pain is not well-controlled with medication and many of the medications cause ...

Phase

Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain

The long-term objective is to reduce overall low back pain (LBP) burden by testing scalable, first-line, non-pharmacologic strategies that address the biopsychosocial aspects of acute/sub-acute LBP and prevent transition to chronic back pain. The US is in the midst of an unprecedented pain management crisis. LBP is the most common ...

Phase

Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain

This project is a randomized controlled trial with the aim of comparing efficacy of image (ultrasound)-guided administration of perineural combination of steroids and local anesthetic (current standard of care) against perineural local anesthetic (LA) or saline in providing sustained analgesic benefit in people with chronic neuropathic pain (NP) of the ...

Phase

Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).

Randomized, double blind study enrolling 200 adults undergoing thoracotomy. Patients receive either 75 mg hydroxyzine before surgery and placebo 3 times daily for 10 days or 1200 mg gabapentin before surgery continued for 10 days. All patients receive also a thoracic epidural analgesia. Assessment of chronic pain at 3 month ...

Phase