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COPD (Chronic Obstructive Pulmonary Disease) Clinical Trials

A listing of COPD (Chronic Obstructive Pulmonary Disease) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (36) clinical trials

A Study on Whether Patients Prefer the Spiriva Respimat or the Spiriva Handihaler for Treating Their Chronic Obstructive Pulmonary Disease (COPD)

The objective of this study is to investigate the patient acceptability/preference of Respimat compared with Handihaler in patients with moderate to severe chronic obstructive pulmonary disease (COPD) to demonstrate the superiority of Respimat.


A Study to Test the Combination of Tiotropium and Olodaterol Using the Respimat Inhaler in People With Chronic Obstructive Pulmonary Disease (COPD) Who Have Different Abilities to Inhale

To demonstrate the efficacy of inhaled tiotropium + olodaterol via Respimat on lung function in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD) with optimal and sub-optimal Peak Inspiratory Flow Rate (PIFR). Disease severity (moderate to severe) is based on the Global Initiative for Chronic Lung Disease (GOLD) ...


A Clinical Study to Investigate if a Single Dose of an Approved Drug Product (Glycopyrrolate Inhalation Solution) Reduces Trapped Air in the Lungs of Participants With Chronic Obstructive Pulmonary Disease.

This is a single center, randomized, double-blind, placebo-controlled, single-dose, 2-way crossover study in approximately 20 adult subjects 40 years of age with COPD. The study is designed to evaluate the effect of a single dose of GIS on lung hyperinflation. The two study treatments, both administered using the Magnair device. ...


Dexamethasone Versus Prednisone in Heart Failure Patients Hospitalized With Exacerbation of Chronic Obstructive Pulmonary Disease.

An Open-label randomized prospective study of HF patients (NYHA grade II-VI), hospitalized with COPD exacerbation. Eighty patients will be randomized in a 1:1 fashion to conventional and intervention testament groups. Informed consent will be obtained from all patients prior to study enrolment. Randomization will be performed using RED cap - ...


Targeted AntiBiotics for Chronic Obstructive Pulmonary Disease

P. aeruginosa represents a potentially significant cause of acute exacerbation of COPD (AECOPD) and is possibly associated with significant morbidity and mortality. Despite this, the role of P. aeruginosa in the course of COPD is less well characterized, and evidence based guidelines for management and treatment of the bacteria are ...


Effects of Long Acting Bronchodilators on CARDiac Autonomic Control in Chronic Obstructive Pulmonary Disease (COPD)

This is a cross-over study with randomization in terms of 4 treatments: two long-acting muscarinic antagonists (tiotropium and glycopyrronium), one long-acting beta-adrenoceptor agonist(indacaterol) and placebo. Each subject will pass 4 experimental random sessions, separated by at least 48 hours given the pharmacokinetic properties of the drugs tested. During each of ...


Morphine or Fentanyl for Refractory Dyspnea in COPD

Rationale: The most important complaint in severe COPD is dyspnea which is associated with a diminished exercise tolerance, reduced quality of life and can lead to anxiety and depression. If dyspnea continues to exist despite optimal therapy it is called refractory dyspnea. There is evidence that morphine is effective and ...


Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators

Dyspnea arises during exercise in COPD patients when there is a mismatch between the ventilatory demand (largely dictated by chemical stimuli) and the capacity to respond to that demand (dictated by mechanical/muscular factors). Our preliminary studies have indicated that treatment with opioids in COPD patients can improve activity related dyspnea ...


Implications of Appropriate Use of Inhalers in Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease associated with substantial morbidity and mortality and is now the 3rd leading cause of death in the United States. The majority of COPD-related symptoms are managed using inhaled therapy. Inhalation is a safe, efficacious and quick way for drug ...