Knee Surgery Clinical Trials

Participation in this research study of an investigational drug could last up to 18 months and include approximately 17 clinic visits. Reimbursement may be provided to qualified participants for time and travel.

Researchers at the University of Kentucky are conducting research to determine the factors associated with long term functional and psychosocial alterations after an ACL reconstruction.

This clinical study is researching a new medication to reduce pain in patients who are having a total knee replacement. The medication is provided intravenously prior to surgery. The study is researching the safety and effectiveness of the medication as well as if it will help reduce the amount of ...

This clinical study is researching a new technology to treat a specific type of knee cartilage injuries. The study is comparing their product and technique to a standardized and regularly performed procedure. Patients who qualify for this trial will receive all study related medication and care at no cost to ...

Researchers at the University of Kentucky College of Health Sciences are inviting you to participate in a study to learn more about dietary intake, physical activity patterns and outcomes in people who have a history of ACL reconstruction. This study involves 5 visits to the University of Kentucky. Your participation ...

Traumatic knee injury is common and highly debilitating. Surgical reconstruction/repair improves knee biomechanics and function, but neuromuscular dysfunction persist for years despite rehabilitation, hindering resumption of normal activities, increasing risk of further injury and, in a majority of patients, hastening the development of knee osteoarthritis (OA). Our goal in this ...

The purpose of this study is to evaluate the effectiveness of physical therapy (PT) plus BFR training compared to PT alone (without BFR training) after ACL reconstruction in patients who require extended limited weight bearing through assessment of patient reported outcomes and functional testing. The hypothesis is that PT plus ...

The clinical study is planned as a double-blind, randomised, treatment-controlled, parallel-group, single-centre exploratory clinical study with the aim to investigate the analgesic efficacy of the Neodolpasse Infusion Solution in comparison to a 75 mg diclofenac only infusion. Patients who meet the inclusion and exclusion criteria will be enrolled to the ...

Tranexamic acid (Amchafibrin) exerts an antihemorrhagic activity by inhibiting the fibrinolytic properties of plasmin. Tranexamic acid binds to plasminogen when it is transformed into plasmin. The activity of the tranexamic acid-plasmin complex on fibrin activity is less than the activity of free plasmin alone. There are two methods of presentation: ...

After being discharged from the hospital, opioids are major source of pain relief for patients. Previous studies show that 71% of patients prescribed opioid medications after thoracic surgery admitted to taking half or less of their prescribed opioid medications. The analysis showed a correlation between the amount of opioids consumed ...