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Colorectal Cancer Clinical Trials

A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found (163) clinical trials

Advanced Geriatric Evaluation and Quality of Life in Colorectal Cancer Surgery

Multicentre, prospective, observational cohort study with a follow up time of one year. After initial diagnosis of CRC subjects will be screened for frailty using validated questionnaires, physical tests and non-invasive measurements. Frailty characteristics and HRQL are determined by Geriatric 8 (G8), Hospital Anxiety and Depression Scale(HADS), Euroqol- 5 dimensional …

Phase N/A

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular …

Phase N/A

Locally Advanced Colorectal Cancer and Local Recurrences in V stra G taland

The aim of this study is to review the treatment strategies of locally advanced colorectal cancer and locally recurrent rectal cancer in Vstra Gtaland during 1995-2016. The aim is to evaluate time trends and outcome both related to morbidity and cancer specific survival, we will also evaluate the results after …

Phase N/A

The AID Study 2: Artificial Intelligence for Colorectal Adenoma Detection 2

Colonoscopy is clinically used as the gold standard for detection of colon cancer (CRC) and removal of adenomatous polyps. Despite the success of colonoscopy in reducing cancer-related deaths, there exists a disappointing level of adenomas missed at colonoscopy. "Back-to-back" colonoscopies have indicated significant miss rates of 27% for small adenomas …

Phase N/A

Real World Study of Regorafenib Versus Fruquintinib in Colorectal Cancer

This is an observational, ambispective cohort study. The aim is to compare the efficacy and safety of regorafenib versus fruquintinib conducted in China. About 268 eligible metastatic colorectal cancer patients after second-line therapy will be assigned to receive either regorafenib or fruquintinib, based on decision of the gastrointestinal physician according …

Phase N/A

Gut Microbiome in Colorectal Cancer

This is a pilot feasibility study designed to investigate the alterations in the gut microbiome that occur during the course of treatment for colorectal cancer (CRC). Three patient cohorts will be followed. Cohort A: patients treated with oral fluoropyrimidine CAP as part of standard of care (SOC) chemotherapy. Cohort B: …

Phase N/A

Survival Analysis of Frail Patients With Localised Colorectal Cancer

Patients with localized colorectal cancer will be visited by a colorectal surgeon who will explain the disease and the surgical treatment. In this visit the patient will be screened for frailty and asked for informed consent. Patients who meet the eligibility criteria will be sent to the internal medicine consultant …

Phase N/A

Improving Colonoscopy Quality for Colorectal Cancer Screening in the National VA Healthcare System

Colorectal cancer (CRC) prevention is a top VA priority. Veterans are highly impacted by CRC, the third most common cancer diagnosed5,6 with a 3-year mortality rate of 35%.5 Colonoscopy screening can save lives, and is the cornerstone of effective prevention. The National Polyp Study showed that removal of adenomas during …

Phase N/A

Urinary and Sexual Dysfunctions Evaluation After Rectal Resection

Advances in the treatment of rectal cancer over the past two decades have improved survival and significantly reduced surgery-related morbidity. As a result, post-treatment quality of life (QoL) issues have become increasingly important. Urinary and sexual functions can be significantly altered after rectal resection, mainly due to the iatrogenic lesions …

Phase N/A

Point of Care Faecal Immunochemical Testing for Colorectal Cancer

Introduction The demand for early diagnosis of bowel cancer In the United Kingdom, there are an estimated 41,700 new cases of bowel cancer diagnosed each year and it is the fourth most common cancer. Over 90% of patients that are diagnosed with the earliest stage of bowel cancer will survive …

Phase N/A