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Colorectal Cancer Clinical Trials

A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (885) clinical trials

ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study

With over 14,000 patients diagnosed annually, colorectal carcinoma (CRC) is the second most frequently invasive malignancy in Australia. By not only diagnosing CRC at an early stage, but also removing precursor adenomas, colonoscopy with polypectomy reduces the risk of developing and dying from CRC. Laterally spreading lesions >= 20mm (LSL) ...

Phase N/A

Clinical Database of Colorectal Robotic Surgery

Since the emergence of minimally invasive technology twenty years ago, as a surgical concept and surgical technique for colorectal cancer surgery, its obvious advantages have been recognized. Laparoscopic technology, as one of the most important technology platform, has got a lot of evidence-based support for the oncological safety and effectiveness ...

Phase N/A

Implementation of Enhanced Recovery After Surgery Program (ERAS) in Colorectal Cancer Surgery a Randomized Controlled Trial

The aim of our study is to determine the effect of implementation of the ERAS (enhanced recovery after surgery) protocol in our institute and its impact on hospital length of stay and outcome of surgery.

Phase N/A

A Study of mRNA-5671/V941 as Monotherapy and in Combination With Pembrolizumab (V941-001)

This study will determine the safety and tolerability and establish a preliminary recommended Phase 2 dose of V941(mRNA-5671/V941) as a monotherapy and in combination with pembrolizumab infusion.


Study to Evaluate Safety & Tolerability of AGI-134 in Solid Tumour

Unresectable solid tumour is a tumour that cannot be removed completely through surgery, radiation therapy, drug treatment or any combination of them. AGI-134 (alpha-Gal) is a synthetic molecule that by intratumoural injection trigger a systemic anti-tumour response. This study will evaluate the safety, tolerability and efficacy of AGI-134 given alone ...


ICG-coated Endoscopic Clip for Tumor Localization

The fluorescent clipping method involves endoscopic clipping a fluorescent clip into the colonic lesion site in advance of surgery, and observing the position of the fluorescence through the colonic wall by a light source of a certain wavelength band during surgery. The purpose of this study is to evaluate the ...

Phase N/A

Encorafenib Cetuximab and Nivolumab in Treating Patients With Microsatellite Stable BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer

PRIMARY OBJECTIVES: I. To describe overall response rate (ORR) upon treatment with encorafenib, cetuximab, and nivolumab. II. To determine the safety and tolerability of nivolumab, encorafenib, and cetuximab. SECONDARY OBJECTIVES: I. To estimate median progression-free survival (PFS) upon treatment with encorafenib, cetuximab, and nivolumab. II. To estimate median overall survival ...


Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System

Human epidermal growth factor receptor 2, (HER2) is overexpressed /amplified in multiple carcinomas, for example, gastric cancer(GC), gastroesophageal junction adenocarcinoma(GEJA),and breast cancer.And HER2 is closely related to tumor proliferation &metastases.About 90% Chinese esophagus cancer are squamous cell origin. The reported HER2 overexpression ranged from 5-30%, Beijing cancer hospital reported an ...


Pembrolizumab After Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and Who Are Undergoing Liver Surgery

PRIMARY OBJECTIVES: I. To characterize the change in the populations of tumor-infiltrating immune cells (TIICs) induced by neoadjuvant pembrolizumab following leucovorin calcium (calcium folinate), 5-fluorouracil, and oxaliplatin (FOLFOX) in patients with metastatic colorectal cancer (CRC). SECONDARY OBJECTIVES: I. To describe the safety/toxicity profile of pembrolizumab following FOLFOX in the preoperative ...


Window of Opportunity Study in Colorectal Cancer

Patients with radiologically-assessed locally advanced non-metastatic colorectal cancer will receive the following treatment before surgery: Colon cancers: One cycle of CAPEOX chemotherapy Two cycles of Pembrolizumab on Day 1 (concurrent with CAPEOX chemotherapy) and Day 22 Rectal cancers: Following completion of chemo-radiotherapy with 5-fluorouracil (5-FU)/ capecitabine, patients will receive 2 ...