Colorectal Cancer Clinical Trials

A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 520 clinical trials
Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors

This open-label, phase Ib/II study of surufatinib in combination with tislelizumab will evaluate the safety, tolerability, PK and efficacy in patients with advanced solid tumors. The study consists of 2 parts - dose finding (Part 1) and dose expansion (Part 2).

systemic therapy
cancer chemotherapy
cancer
BRAF
adenocarcinoma
  • 2 views
  • 26 Apr, 2022
  • 16 locations
A Study of RGX-202-01 as a Single Agent and as Combination Therapy in Patients With Advanced Gastrointestinal Malignancies

patients with colorectal cancer (CRC) selected by expression of the creatine kinase B (CKB) biomarker will be treated at the MTD (or maximum tested dose if no MTD is identified, or dose below the MTD if

neutrophil count
pembrolizumab
irinotecan
bevacizumab
insulin
  • 309 views
  • 24 Jul, 2022
  • 7 locations
A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors (AMPLIFY-201)

This is a Phase 1 study to assess the safety and efficacy of ELI-002 immunotherapy (a lipid-conjugated immune-stimulatory oligonucleotide [Amph-CpG-7909] plus a mixture of lipid-conjugated peptide-based antigens [Amph-Peptides]) as adjuvant treatment of minimal residual disease (MRD) in subjects with KRAS/neuroblastoma ras viral oncogene homolog (NRAS) mutated PDAC or other solid …

NRAS
cancer chemotherapy
KRAS
  • 12 views
  • 27 Jul, 2022
  • 8 locations
R vs L Lateral Decubitus Positioning in Colonoscopy

Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions. Visualization is improved with luminal distention, and a multitude of studies have been done to determine ways to increase this luminal …

Accepts healthy volunteers
adenoma
luminal
  • 14 views
  • 27 Apr, 2022
  • 1 location
Assessing How the Viscosity of Submucosal Gel Injections Helps With Endoscopic Mucosal Resections

This is a study to determine how the viscosity (thickness) of an FDA approved gel affects the ease in which endoscopic mucosal resections (EMR) can be performed.

gastrectomy
colectomy
  • 3 views
  • 26 Apr, 2022
  • 1 location
Endoscopic Full Thickness Resection Versus Standard Therapy of the Colorectal Neoplasia

Most of the cancers develop from the adenomatous polyps. The therapeutic methods have been established already - endoscopic polypectomy (EPE) for stalked polyps and endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) for non-pedunculated polyps. EMR is preferred in European countries over ESD because of its higher feasibility. However, …

  • 0 views
  • 03 May, 2022
  • 1 location
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.

Primary Objective • To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives To determine if short-term treatment with TVB-2640 decreases cancer cell proliferation. To examine other biological endpoints and determine if TVB-2640 inhibits cell …

metastasis
Accepts healthy volunteers
  • 4 views
  • 24 May, 2022
  • 1 location
A Study of Perioperative Oral Nutritional Support for Patients Having Surgery for Colon Cancer, Peri-Nutri

This is a multicenter, unblinded, randomized study. The aim of this study is to research whether preoperative and postoperative oral nutritional supplement (ONS) (Resource 2.5 Compact/fibre compact) used at least 2 weeks prior the surgery and 10 days after surgery can improve the nutritional status of a colon cancer patient …

malnutrition
adenocarcinoma of colon
nutritional supplementation
cancer
adenocarcinoma
  • 3 views
  • 27 May, 2022
  • 1 location
Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON)

Comparing different method of surgical technique D2 lymph node dissection vs D3 for right colon cancer.

adenocarcinoma
hemicolectomy
transverse colon cancer
  • 68 views
  • 08 Aug, 2022
  • 1 location
Safety and Efficacy of Atezolizumab Combined to Preoperative Radio-chemotherapy in Localized Rectal Cancer (R-IMMUNE)

The study has a phase Ib and a phase II part. The phase Ib part of the study aims to determine the safety and tolerance of administration at a fixed dosing of 1200 mg / 3 weeks, concomitantly to the standard preoperative radio-chemotherapy. The phase II part of the study …

neutrophil count
cancer
fluorouracil
adenocarcinoma
rectal carcinoma
  • 0 views
  • 20 Apr, 2022
  • 4 locations