Colorectal Cancer Clinical Trials

A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 540 clinical trials
Safety and Feasibility Study of Robotic Assisted Transanal Total Mesorectal Excision for Rectal Cancer

Total mesorectal excision has greatly reduced the local recurrence rate of rectal cancer after colorectal surgery. Transanal total mesorectal excision(TaTME) is potentially a suitable option for patients with middle and low rectal cancer. Robotic systems are expected to develop the advantages of TaTME to overcome the limitations of laparoscopic surgery. …

adenocarcinoma
total mesorectal excision
  • 0 views
  • 06 May, 2022
  • 1 location
Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients (WW3)

In recent years, an increasing number of retrospective and prospective observational studies have indicated that a subset of rectal cancer patients may avoid surgery if they can achieve a complete response to chemoradiotherapy. Prospective trials, including the previous Danish Watchful Waiting trials (NCT00952926, NCT02438839) in early rectal cancer have demonstrated …

adenocarcinoma
capecitabine
chemo-radiotherapy
proctectomy
chemoradiotherapy
  • 2 views
  • 07 Jun, 2022
  • 3 locations
Enhanced Recovery After Laparoscopic Colorectal Surgery

We would like to test the effects of spinal anesthesia as an adjunct to general anesthesia in patients undergoing laparoscopic abdominoperineal rectal amputation. We hypothesize that spinal anesthesia as an adjunct to general anesthesia will reduce postoperative pain and opioid requirements.

  • 0 views
  • 20 Jun, 2022
  • 1 location
FOLFOXIRI With or Without Intensification for Rectal Cancer

Pathologic complete response rate

measurable disease
adenocarcinoma
capecitabine
adenocarcinoma of rectum
  • 0 views
  • 23 Jul, 2022
  • 1 location
Chemotherapy Followed by Pelvic Reirradiation Versus Chemotherapy Alone as Pre-operative Treatment for Locally Recurrent Rectal Cancer (GRECCAR15)

GRECCAR 15 is focused on Locally Recurrent Rectal Cancer (LRRC) for patients with previous pelvic radiotherapy for the primary rectal cancer. This situation leads to a 20% higher risk of non-curative resection for the LRRC management (R1 status) impacting significantly the overall survival. The widespread use of neoadjuvant radiotherapy for …

capecitabine
metastasis
irinotecan
curative surgery
renal function
  • 0 views
  • 24 Jul, 2022
  • 15 locations
Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is performed to remove the tumor.

capecitabine
proctoscopy
chemoradiotherapy
oxaliplatin
anticoagulants
  • 2 views
  • 25 Jul, 2022
  • 1 location
Capecitabine Plus Concomitant Radiation Therapy Followed by Durvalumab as Preoperative Treatment in Rectal Cancer (PANDORA)

This is a prospective phase II, open label, single arm, multi-centre study to evaluate activity of an innovative sequence on capecitabine plus concomitant radiation therapy followed by durvalumab in patients with operable rectal cancer. The enrollment period will be of 12 months. Eligible patients will be initiated to a standard …

adenocarcinoma
capecitabine
chemoradiation therapy
chemoradiotherapy
durvalumab
  • 7 views
  • 28 Jul, 2022
  • 1 location
Neoadjuvant Chemoradiation Therapy Combined With Immunotherapy for MSS Ultra-low Rectal Cancer

At present, there are no relevant studies or reports on the effect of neoadjuvant chemoradiation therapy combined with immunotherapy for MSS ultra-low rectal cancer. Studied in this paper combin neoadjuvant chemoradiation with immune therapy, carry out "Multicenter prospective randomized clinical trial of neoadjuvant chemoradiation therapy combined with immunotherapy for MSS …

  • 0 views
  • 29 Jul, 2022
  • 1 location
SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer (SHORT)

TASOX can be safely and efficaciously delivered after short course radiation, resulting in significant pathologic downstaging, allowing for an R0 pelvic resection, and providing local control in appropriately selected stage II/III rectal cancer patients treated with contemporary TME-based surgery.

adenocarcinoma
metastasis
pelvic mri
tas-102
total mesorectal excision
  • 0 views
  • 29 Jul, 2022
  • 3 locations
A Safety Study Adding Niraparib and Dostarlimab to Radiation Therapy for Rectal Cancers

This clinical trial is designed to determine the maximum tolerated dose of niraparib when combined with dostarlimab and hypofractionated radiation for locally advanced rectal cancer. Once this is determined, this dose will be tested to identify what impact it has on the tumor as well as patient reported outcome measures.

monoclonal antibodies
  • 0 views
  • 08 Aug, 2022
  • 1 location