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Colorectal Cancer Clinical Trials

A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (17) clinical trials

Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer

PRIMARY OBJECTIVES: I. To determine whether, compared to placebo, linaclotide administered as a single oral daily dose x 7 days, induces a pharmacodynamics (PD) effect on cGMP levels, based on biopsy samples of adenomas or resected colorectal adenocarcinomas. SECONDARY OBJECTIVES: I. To compare Ki-67, guanylin levels and GUCY2C expression in ...


Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis

This will be a prospective single arm biomarker (plasma-free DNA 5-hydroxymethylation) study. Fifty-five Adult patients with peritoneal metastases of colorectal and appendiceal origin who are candidates for a curative surgery and fulfill the inclusion criteria will be offered to participate in this study. In addition to the postoperative standard of ...

Phase N/A

Mycotoxin Exposure and Dietary Habits in Colorectal Cancer Prevention and Development Among Polish Population

The aim of the study is the determination of the zearalenone and its metabolites ( and ) level in the blood plasma and faeces of patients at increased risk of cancer, in relation to the nutrition data (FFQ) and information on the quality of life dependent on health (WHOQOL-BREF). The ...

Phase N/A

Mindfulness Meditation and Qigong for Colorectal Cancer Survivors

Colorectal cancer is one of the most common forms of cancer. Lifestyle modification and development of self-regulatory and self-care skills for maintaining psychological and physical well-being are especially important for recurrence prevention and long-term illness management. Mind-body practices are popular among cancer patients for being non-pharmacological, holistically beneficial, in addition ...

Phase N/A

Effect of Atorvastatin on 5-Fluorouracil Induced Mucositis

Chemotherapy has life-threatening or distressing side effects such febrile neutropenia, infections, mucositis, nausea, vomiting, fatigue. Mucositis is dened as inammatory and/or ulcerative lesions of the oral and/or gastrointestinal tract that can be caused by high dose chemotherapy, Infectious disease, immune deciency and medications.. Lesions of oral mucositis (OM) are often ...

Phase N/A

Endoscopic Versus Surgical Treatment for T1 Colorectal Cancer

The primary objective of the study is to compare the effect of oncological surgery versus local treatment for the management of polyps with T1 CRC in relation to disease-free survival and morbi-mortality of the therapeutic procedure. We will also validate molecular signatures in endoscopic samples for the prediction of lymph ...

Phase N/A

Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer

Colorectal cancer (CRC) is responsible for 10% of the world-wide cancer incidence and mortality. Recent data have shown that tumors arising from different regions of the colon differ in their molecular characteristics which causes translate into a differential clinical outcome.Several studies described the role of microRNA expression in the initiation ...

Phase N/A

A Study of SGN-CD228A in Advanced Solid Tumors

This study is designed to evaluate the safety, tolerability, PK, and antitumor activity of SGN-CD228A in select advanced solid tumors. The study will include dose escalation and dose expansion, with multiple disease-specific expansion cohorts.


Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status

Arethusa consists of three different phases - SCREENING Phase, PRIMING phase, and TRIAL Phase. SCREENING PHASE: RAS-mutated metastatic CRC patients are tested for MMR status. MMR-Deficient (MMR-D) patients proceed directly to TRIAL Phase and are treated with pembrolizumab. MMR-Proficient (MMR-P) patients are further tested for O6-methylguanine-DNA methyltransferase (MGMT) expression by ...


TAS-102 Irinotecan and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer the TABAsCO Study

PRIMARY OBJECTIVE: I. Determine the median progression free survival (PFS) benefit of leucovorin calcium, 5-fluorouracil, and irinotecan (FOLFIRI) naive patients treated with trifluridine and tipiracil hydrochloride (TAS-102) + irinotecan + bevacizumab as compared to historic control groups treated with FOLFIRI + bevacizumab. SECONDARY OBJECTIVE: I. Estimate the objective response rate ...