Islet Ce417ll Cancer Clinical Trials

A listing of Islet Ce417ll Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 220 clinical trials
Precision-Panc Master Protocol: Personalising Treatment for Pancreatic Cancer

The Precision-Panc Master Protocol is a "portal" protocol for patients with known or suspected pancreatic cancer to be accrued through multiple centres in the UK, with the option of being subsequently enrolled into PRIMUS (Pancreatic canceR Individualised Multi-arm Umbrella Studies) examining different treatment regimens and/or biomarker development. Eligible patients will …

pancreatic ductal adenocarcinoma
metastasis
breast ductal carcinoma
cancer chemotherapy
adenocarcinoma
  • 23 views
  • 26 May, 2022
  • 29 locations
Comparing Two Methods to Follow Patients With Pancreatic Cysts

The purpose of this study is to compare the two approaches for monitoring pancreatic cysts. The study doctors want to compare more frequent monitoring vs less frequent monitoring in order to learn which monitoring method leads to better outcome for patients with pancreatic cysts.

pancreatitis
endoscopic ultrasound
pancreatic resection
pancreatic adenocarcinoma
adenocarcinoma
  • 67 views
  • 04 Oct, 2022
  • 193 locations
Combination of Anti-PD-1 Antibody and Chemotherapy in Pancreatic Cancer

The prognosis of pancreatic cancer is extremely poor. Current guidelines recommend FOLFIRINOX or modified-FOLFIRINOX as the first-line chemotherapeutic regimen. Studies have shown that immunotherapy with Anti-PD-1 antibody can effectively increase the response rate and prolong patient survival in a number of cancer diseases. Here investigators intend to compare the therapeutic …

pdac
pancreatic ductal adenocarcinoma
biliary obstruction
neutrophil count
monoclonal antibodies
  • 32 views
  • 09 Feb, 2022
  • 1 location
Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 is Administered in Combination With IV Modified FOLFIRINOX (mFFX) With or Without IV Budigalimab Compared to mFFX in Adult Participants With Untreated Pancreatic Cancer Metastasis

Metastatic Pancreatic Cancer Disease is one of the most aggressive and deadliest forms of cancer with very poor survival. This study will evaluate adverse events and change in disease activity in participants 18 to 75 years of age with a body weight greater than or equal to 35 kg with …

metastasis
folfirinox
pancreatic adenocarcinoma
measurable disease
adenocarcinoma
  • 2 views
  • 04 Jun, 2022
  • 15 locations
A Phase 2, Open-Label, Randomized Study to Assess the Efficacy and Safety of Zolbetuximab (IMAB362) in Combination With Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects With Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma

The purpose of this study is to confirm the recommended phase 2 dose (RP2D) of zolbetuximab in combination with Nab-P + GEM, determine overall survival and assess the safety and tolerability of the combination treatment. This study will also evaluate tumor markers and pharmacokinetics (PK) of zolbetuximab, Nab-P and GEM, …

tumor cells
paclitaxel
measurable disease
international normalized ratio
metastatic pancreatic adenocarcinoma
  • 251 views
  • 21 Oct, 2022
  • 89 locations
A First-in-human Phase Ia/b, Open Label, Multicentre, Dose Escalation Study of BI 905711 in Patients With Advanced Gastrointestinal Cancers

Phase Ia - Explore safety and establish the maximum tolerated dose (MTD)/recommended dose levels for phase Ib expansion phase of BI 905711 based on the frequency of patients experiencing dose limiting toxicities (DLTs) during the MTD evaluation period. The MTD evaluation period is defined as the first two treatment cycles …

lipase
colorectal adenocarcinoma
esophageal adenocarcinoma
carcinoma
pancreatic adenocarcinoma
  • 76 views
  • 20 Oct, 2022
  • 14 locations
The Cancer of the Pancreas Screening-5 CAPS5)Study (CAPS5)

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

fammm
ca19-9
pancreatitis
secretin
palb2
  • 185 views
  • 04 Oct, 2022
  • 8 locations
OPTimizing Treatment Focused Genetic Testing IN Cancer (OPT-IN)

This two-part randomized controlled trial aims to evaluate the impact of pre-test video education as compared to pre-test Chatbot education.

  • 0 views
  • 02 May, 2022
  • 1 location
A Master Protocol of Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy (SMART)

This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer. The phase 1 study will evaluate the feasibility and safety of delivering SMART in patients with cancer. Phase 2 will evaluate efficacy of SMART …

stereotactic body radiation therapy
primary cancer
cancer
  • 0 views
  • 18 Oct, 2022
  • 1 location
A Phase 2 Basket Study of the Oral TRK Inhibitor Larotrectinib in Subjects With NTRK Fusion-positive Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

breast cancer
tyrosine
NTRK
lung cancer
measurable disease
  • 163 views
  • 21 Oct, 2022
  • 125 locations