Neoplasms Clinical Trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 17429 clinical trials
A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants With Multiple Myeloma

This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the …

serum calcium
cell transplantation
cancer
bortezomib
dexamethasone
  • 4 views
  • 11 Aug, 2022
  • 75 locations
A Phase 1 Open-label, Multicenter, Dose Escalation Study of the Safety, Tolerability, and PK of HPN217 in Patients With R/R MM

An open-label, Phase 1 study of HPN217 to assess the safety, tolerability and PK in patients with relapsed/ refractory multiple myeloma

neutrophil count
measurable disease
renal function
refractory multiple myeloma
proteasome inhibitor
  • 40 views
  • 11 Aug, 2022
  • 14 locations
A Study of TNB-383B in Participants With Relapsed or Refractory Multiple Myeloma

This is a phase 1, open-label study evaluating the safety, clinical pharmacology and clinical activity of TNB-383B, a BCMA x CD3 T-cell engaging bispecific antibody, in participants with relapsed or refractory MM who have received at least 3 prior lines of therapy. The study consists of 4 portions, a monotherapy …

neutrophil count
measurable disease
serum calcium
bone marrow procedure
calcium
  • 12 views
  • 11 Aug, 2022
  • 10 locations
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Background Researchers are interested in studying individuals who have known or suspected metabolic or genetic diseases that put them at a high risk for heart diseases or diseases of their blood vessels. To improve the results of the study, both affected and nonaffected individuals will be asked to provide blood …

cardiovascular disease
heart disease
walk test
MRI
angiography
  • 167 views
  • 03 Jun, 2022
  • 1 location
Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma (DREAMM 9)

This study will evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of belantamab mafodotin in combination with Velcade (bortezomib), Revlimid (lenalidomide), dexamethasone (VRd) and will determine recommended phase 3 dose (RP3D) in adult participants with newly diagnosed multiple myeloma (NDMM). Participants will receive the combination of bortezomib, lenalidomide and dexamethasone …

neutrophil count
measurable disease
cell transplantation
lenalidomide
bortezomib
  • 14 views
  • 09 Aug, 2022
  • 31 locations
Ovarian Contribution to Androgen Production in Adolescent Girls

Women with polycystic ovary syndrome (PCOS) can have unwanted facial or male-patterned body hair, irregular menstrual periods, or no menstrual periods excess body weight, and infertility. It also results in elevated androgen levels such as testosterone. In women with PCOS, the majority of excess androgens are produced by the ovaries. …

androgens
testosterone level
prolactin
insulin
sex hormones
  • 42 views
  • 27 Jan, 2021
  • 1 location
Prevalence of Hyperandrogenism in Type 1 Diabetes

The investigators aim to estimate the prevalence of functional ovarian hyperandrogenism [idiopathic hyperandrogenism, idiopatic hirsutism, and polycystic ovary syndrome (PCOS)] in adult patients with type 1 diabetes (T1DM) in an observational cross-sectional study. Study population is comprised of premenopausal adult women with a diagnosis of T1DM, consecutively recruited from a …

testosterone level
retinopathy
nephropathy
hypertension
diabetes
  • 0 views
  • 22 Apr, 2022
  • 1 location
Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Idiopathic Inflammatory Diseases of the Nervous System (CARTinNS)

Antibody-mediated idiopathic inflammatory diseases of the nervous system (also known as autoimmune diseases of the nervous system) are autoimmune diseases in which autoimmune cells and immune molecules attack the nervous system as the main pathogenic mechanism. In the immune response, pathogenic antibodies acting on autoantigens of the nervous system are …

neutrophil count
neurological disorders
cell counts
cyclophosphamide
neuritis
  • 0 views
  • 08 Jul, 2022
  • 1 location
Inositol Supplementation to Treat PCOS (INSUPP-PCOS) (INSUPP-PCOS)

To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).

oligomenorrhea
androgens
testosterone level
anovulatory
free androgen index
  • 826 views
  • 24 Jul, 2022
  • 1 location
Administration of Kisspeptin to Subjects With Reproductive Disorders

The investigators are seeking participants for a study of the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occuring hormone in humans that stimulates the production of reproductive hormones. The investigators hypothesize that kisspeptin administration will be a useful tool for characterizing certain reproductive disorders.

kisspeptin
estradiol
replacement therapy
acne
testicular
  • 808 views
  • 22 Jul, 2022
  • 1 location