Neoplasms Clinical Trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 17416 clinical trials
Frailty Score-guided Dosing of Lenalidomide, Dexamethasone and Daratumumab Induction Therapy

The purpose of this study is to determine if using a subject's baseline frailty score to guide the dosing of lenalidomide in a combination with dexamethasone and daratumumab (DRd lite).

dexamethasone
lenalidomide
  • 0 views
  • 23 Mar, 2022
  • 1 location
Examination of Vertebroplasty in Addition to Regular Treatment of Patients With Multiple Myeloma.

Patients with newly diagnosed or known multiple myeloma with newly diagnosed vertebral lesion(s) will be invited to participate in a cross-sectoral randomized controlled trial. The trial will compare two groups of patients which either receive regular medical treatment of their vertebral lesion(s) or vertebroplasty in addition to regular medical treatment. …

  • 0 views
  • 29 Sep, 2021
  • 1 location
Effect of Sleep Quality on Hematopoietic Cell Transplant Patient Outcomes

This randomized, controlled study will compare Mindfulness Awareness Practices for Insomnia (MAP-I) to sleep health education (SHE) in subjects receiving autologous hematopoietic cell transplant for multiple myeloma.

melphalan
  • 0 views
  • 27 Sep, 2021
  • 1 location
Efficacy and Safety of Carfilzomib in Combination With Ibrutinib vs Ibrutinib in Waldenström's Macroglobulinemia (CZAR-1)

In Waldenström macroglobulinemia (WM) chemotherapy induces only low CR/VGPR (Complete Remission/ Very Good Partial Response) rates and responses of short duration compared to other indolent lymphomas. Thus, innovative approaches are needed which combine excellent activity and tolerability in WM. Chemotherapy-free approaches are highly attractive for this patient group. Based on …

cold agglutinin
fever
neutrophil count
dexamethasone
tumor cells
  • 0 views
  • 09 Apr, 2022
  • 14 locations
Autologous Memory-like NK Cell Therapy With BHV-1100 (Formerly KP1237), Low Dose IL-2 in Multiple Myeloma Patients

This is an open-label single center Phase 1a/1b study with the primary objective of establishing the safety and exploring the efficacy of infusing the ex vivo combination product of cytokine induced memory-like (CIML) NK cells plus KP1237 and low dose IL-2 in newly diagnosed MM patients who have minimal residual …

measurable disease
chemotherapy regimen
bone marrow procedure
  • 0 views
  • 25 Mar, 2022
  • 1 location
Study to Evaluate the Safety and Tolerability of CC-92328 in Participants With Relapsed and/or Refractory Multiple Myeloma

This Phase 1, first-in-human (FIH), clinical study of CC-92328 will explore the safety, tolerability and preliminary biological and clinical activity of CC-92328 as a single-agent in the setting of relapsed and/or refractory multiple myeloma (R/R MM). The study will be conducted in two parts: monotherapy dose escalation (Part A) and …

measurable disease
refractory multiple myeloma
  • 0 views
  • 22 Mar, 2022
  • 5 locations
Bortezomib Isatuximab Cyclophosphamide and Dexamethasone Induction in Transplant-Eligible Multiple Myeloma Patients

This is a single-arm, open-label phase II study with a safety lead-in phase.

bortezomib
cell transplantation
dexamethasone
measurable disease
hypercalcemia
  • 0 views
  • 21 Nov, 2021
  • 1 location
Comparison of Two Web-Based Education/Support Programs for Partner Caregivers of People With Spinal Cord Injury

The purpose of this research study is to compare the effect of two different types of education and support programs for partner caregivers of people with spinal cord injury (SCI).

spinal cord disorder
Accepts healthy volunteers
spinal cord
  • 0 views
  • 19 Nov, 2021
  • 1 location
Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patients (ClaSPd)

The purpose of this study is to determine the efficacy and safety of investigational combination therapy of Selinexor, Clarithromycin, Pomalidomide and Dexamethasone (ClaSPd) for patients with relapsed/refractory multiple myeloma. The hypothesis is that the addition of Selinexor to Clarithromycin, Pomalidomide and Dexamethasone will increase the overall response rate of patients …

measurable disease
refractory multiple myeloma
dexamethasone
  • 0 views
  • 21 Mar, 2022
  • 2 locations
ACALA-R In Anti-MAG Neuropathy Mediated Neuropathy

In this research study, is combining a new treatment acalabrutinib with a standard treatment, rituximab or other CD20 antibody, to determine whether this combination is safe and effective for participants with Immunoglobulin (Ig) M monoclonal gammopathy of undetermined significance ( IgM MGUS) or Waldenström macroglobulinemia WM related neuropathies. The names …

serum pregnancy test
antihistaminic
neutrophil count
bone marrow procedure
nerve conduction studies
  • 0 views
  • 25 Mar, 2022
  • 2 locations