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Acute Respiratory Distress Syndrome (ARDS) Clinical Trials

A listing of Acute Respiratory Distress Syndrome (ARDS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (94) clinical trials

Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome

Patients in intensive care units (ICUs) as a result of injuries resulting from penetrating or non-penetrating trauma who are intubated and receiving invasive mechanical ventilation will be randomized to either usual care or usual care with the addition of sigh breaths given once every 6 minutes. Patients will be randomized ...

Phase N/A

MICU Recovery Clinic

Objectives To evaluate physical function, cognitive function, and overall functional status during recovery from critical illness. To evaluate anxiety, depression, and PTSD during recovery from critical illness. To evaluate resilience during recovery from critical illness. To evaluate healthcare utilization rates, morbidity, and mortality following critical illness. Added April 2016: To ...

Phase N/A

Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure

Study Design: This is an observational quality improvement study comparing outcomes before, and after, implementation of a proven lung protective ventilation protocol in an electronic medical record system, iCentra, that will be implemented in phases across Intermountain Healthcare hospitals. A phased implementation with a two-month washout period will be used ...

Phase N/A

PGE1 as Additive Anticoagulant in ECMO-Therapy

Prostaglandins may inhibit platelet activation via the P2Y1 ADP receptor. Platelets may contribute to thromboembolic complications and coagulation activation during ECMO therapy. Retrospective data suggest that treatment with PGE1 may serve beneficial by reducing the amount of heparin needed for inhibition of coagulation activation, and by reducing the thromboembolic risk ...


ECCO2R - Mechanical Power Study

Although mechanical ventilation remains the cornerstone of ARDS treatment, several experimental and clinical studies have undoubtedly demonstrated that it can contribute to high mortality through the developing of ventilator induced lung injury even in patients with plateau pressure <30 cmH2O. Since now there are no studies exploring the application of ...

Phase N/A

A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients

To titrate PEEP guided by EIT. A global inhomogeneity (GI) index and regional compliance based on EIT were developed to quantify the tidal volume distribution within the lung. The aim of this study was to test the feasibility of optimizing PEEP with respect to ventilation homogeneity using the GI index ...

Phase N/A

Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle

We implement a PARDS ventilation bundle compliant with PALICC recommendations. The bundle contains a daily checklist for ventilation targets and reference tables listing targeted tidal volumes and end expiratory pressure-fraction of inspired oxygen titration. We will recruit mechanically ventilated patients who meet PARDS criteria. After a one-month implementation period, we ...

Phase N/A

Long Term Follow up of Children Enrolled in the REDvent Study

Background and Significance: Through advancements in critical care, PARDS mortality has decreased from 50% to less than 20%. Therapeutic strategies for PARDS have sought to improve survival, but have often ignored morbidity, despite extensive evidence that nearly 50% of adult ARDS survivors are left with significant abnormalities in pulmonary, physical, ...

Phase N/A

Hospital-wide Incidence Clinical Characteristics and Outcomes of ARDS

We hypothesize that the hospital-wide incidence of ARDS, as defined by the Kigali modification, is similar in high resource settings (e.g., Boston and Toronto) as compared to the resource-constrained setting of Kigali, Rwanda. We also hypothesize that pulmonary ultrasound is a more sensitive and similarly specific imaging modality for bilateral ...

Phase N/A


Introduction: The Mechanical Ventilation (MV), a support method used in Intensive Care Units (ICU), reaches approximately 90% of critical patients whose withdrawal process represents 40% of the total time of their use. For this purpose Transcutaneous electrical diaphragmatic stimulation (TEDS), which by means of electrodes placed in motor action points ...

Phase N/A